Linked Life Data

1171044

Source:http://linkedlifedata.com/resource/pubmed/id/1171044

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-11-6
pubmed:abstractText
Plasma levels of nonconjugated estrone (E1), estradiol-17beta (E2), and estriol (E3) and excretion of these estrogens in urine in conjugated and nonconjugated forms were measured by radioimmunoassay in 17 healthy males and 33 males with alcoholic liver disease. Patients with liver disease had significantly elevated plasma levels of E1 (74.2 +/- 8.0 SE versus 26.0 +/- 1.7 pg per ml, P less than 0.001), E2 (29.3 +/- 2.2 versus 23.3 +/- 2.0 pg per ml, P = less than 0.05), and E3 (11.5 + 1.9 versus 6.5 +/- 0.7 pg per ml, P less than 0.01). Excretion of total E1, E2, and E3 in urine was significantly increased in patients with liver disease; the increase was primarily in the nonconjugated fraction. Among those patients with chronic liver disease, the presence of ascites was associated with significantly higher plasma levels of E1 and excretion of larger amounts of E1 and E2 in urine. On the other hand, no differences were observed in the small number of patients with gynecomastia. A direct correlation between the plasma level or excretion of E1 or E2 and several liver function abnormalities was observed. The relative hyperestrogenemia we report here may account for some of the clinical observations in chronic liver disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
20-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Plasma levels and excretion of estrogens in urine in chronic lever disease.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.