|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2001-11-15
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1534-5807
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
1
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
655-65
|
|
pubmed:dateRevised |
2007-12-11
|
|
pubmed:meshHeading |
pubmed-meshheading:11709186-Amino Acid Sequence,
pubmed-meshheading:11709186-Animals,
pubmed-meshheading:11709186-Central Nervous System,
pubmed-meshheading:11709186-Choristoma,
pubmed-meshheading:11709186-Cloning, Molecular,
pubmed-meshheading:11709186-Embryonic Induction,
pubmed-meshheading:11709186-Eye,
pubmed-meshheading:11709186-Head,
pubmed-meshheading:11709186-Humans,
pubmed-meshheading:11709186-In Situ Hybridization,
pubmed-meshheading:11709186-Insulin-Like Growth Factor Binding Protein 5,
pubmed-meshheading:11709186-Insulin-Like Growth Factor I,
pubmed-meshheading:11709186-Insulin-Like Growth Factor II,
pubmed-meshheading:11709186-Mesoderm,
pubmed-meshheading:11709186-Molecular Sequence Data,
pubmed-meshheading:11709186-Phylogeny,
pubmed-meshheading:11709186-RNA, Messenger,
pubmed-meshheading:11709186-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11709186-Sequence Homology, Amino Acid,
pubmed-meshheading:11709186-Signal Transduction,
pubmed-meshheading:11709186-Somatomedins,
pubmed-meshheading:11709186-Xenopus laevis
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Neural and head induction by insulin-like growth factor signals.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles 90095, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
