Source:http://linkedlifedata.com/resource/pubmed/id/11707114
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
46
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pubmed:dateCreated |
2001-11-14
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pubmed:abstractText |
The stereospecific total synthesis of (+/-)-thielocin A1beta has been achieved from the common intermediate ethyl 5-formyl-2,4-dihydroxy-3,6-dimethyl benzoate (8). The racemic synthesis was achieved based on the key reaction of a 4-methyl-3,4-dihydroxy cyclohexadienone 38 with a quinone methide derived at low temperature from the fluoride ion catalyzed composition of piperidinium salt 40. The resulting condensate (31) was homologated by successive esterification with protected monomeric phenol 41 to provide, after careful removal of the protecting groups, the desired thielocin A1beta.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0002-7863
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11381-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11707114-Animals,
pubmed-meshheading:11707114-Humans,
pubmed-meshheading:11707114-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11707114-Mass Spectrometry,
pubmed-meshheading:11707114-Phosphodiesterase Inhibitors,
pubmed-meshheading:11707114-Phospholipases A,
pubmed-meshheading:11707114-Rats,
pubmed-meshheading:11707114-Spectrophotometry, Infrared,
pubmed-meshheading:11707114-Stereoisomerism,
pubmed-meshheading:11707114-Synovial Fluid,
pubmed-meshheading:11707114-Xanthenes
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pubmed:year |
2001
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pubmed:articleTitle |
Stereoselective total synthesis of (+/-)-thielocin A1beta.
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pubmed:affiliation |
Merck Frosst Centre for Therapeutic Research, P.O. Box 1005, Pointe Claire-Dorval, Québec, Canada H9R 4P8.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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