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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2001-11-13
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pubmed:abstractText |
In the absence of interleukin-4 (IL-4), infection with Schistosoma mansoni leads to a severe fatal disease rather than the chronic survivable condition that occurs in wild-type (WT) mice. Because the sustained production of NO most closely correlates to weight loss and fatality in infected IL-4(-/-) mice and because gamma interferon (IFN-gamma) is an important inducer of inducible NO synthase, infected IL-4(-/-) mice were treated with anti-IFN-gamma antibodies to determine the role of IFN-gamma during schistosomiasis in WT and IL-4(-/-) animals. When IFN-gamma was neutralized, Th2 responses were enhanced and NO production was reduced in both WT and IL-4(-/-) mice. The decreased NO production correlated with a rescue of proliferation in splenocytes from infected IL-4(-/-) mice. Furthermore, the neutralization of IFN-gamma in vivo improved the gross appearance of the liver and led to a reduction in granuloma size in infected IL-4(-/-) but not WT mice. However, the neutralization of IFN-gamma in vivo did not affect the development of severe disease in infected IL-4(-/-) mice. These results suggest that while the increased production of IFN-gamma does lead to some of the pathology observed in infected IL-4(-/-) mice, it is not ultimately responsible for cachexia and death.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-10229817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-10384133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-10491413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-10528202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-10661403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-10679097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-10706693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-10843696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-10980133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-11063861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-11119559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-11160238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-1824635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-1825109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-2642947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-2970507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-3119723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-3139757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-4957633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-5313073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-5535626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-7181105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-7706739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-7825222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-7904772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-8602458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-8671630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-9199423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-9218595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-9435251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-9469463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-9590248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-9603480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-9645618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11705919-9692887
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7445-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11705919-Animals,
pubmed-meshheading:11705919-Antibodies, Monoclonal,
pubmed-meshheading:11705919-Antigens, Helminth,
pubmed-meshheading:11705919-Cell Division,
pubmed-meshheading:11705919-Female,
pubmed-meshheading:11705919-Interferon-gamma,
pubmed-meshheading:11705919-Interleukin-4,
pubmed-meshheading:11705919-Liver,
pubmed-meshheading:11705919-Mice,
pubmed-meshheading:11705919-Mice, Mutant Strains,
pubmed-meshheading:11705919-Neutralization Tests,
pubmed-meshheading:11705919-Nitric Oxide,
pubmed-meshheading:11705919-Schistosomiasis mansoni,
pubmed-meshheading:11705919-Spleen,
pubmed-meshheading:11705919-Th2 Cells
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pubmed:year |
2001
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pubmed:articleTitle |
Role of gamma interferon in the pathogenesis of severe schistosomiasis in interleukin-4-deficient mice.
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pubmed:affiliation |
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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