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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-11-12
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pubmed:abstractText |
In glomerular hypertension, mesangial cells (MC) are subjected to at least two physical forces: a high pressure and mechanical stretch. In 5/6 nephrectomized rat, a model of progressive glomerular sclerosis associated with glomerular hypertension, monocyte chemoattractant protein-1 (MCP-1) is expressed in glomeruli, suggesting the possible role of MCP-1 in the pathogenesis of glomerular sclerosis; however, whether pressure directly affects MCP-1 expression remains undetermined. Here we examined the effects of pressure on MCP-1 expression in cultured rat MC and the signal transduction pathways that lead to MCP-1 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0085-2538
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pubmed:author |
pubmed-author:AnaiHH,
pubmed-author:IwamotoMM,
pubmed-author:KabashimaNN,
pubmed-author:KanegaeKK,
pubmed-author:KatzEE,
pubmed-author:NakashimaYY,
pubmed-author:OkazakiMM,
pubmed-author:OsajimaAA,
pubmed-author:OtaTT,
pubmed-author:SudaTT,
pubmed-author:TamuraMM,
pubmed-author:TanakaHH
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1705-15
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11703588-Animals,
pubmed-meshheading:11703588-Chemokine CCL2,
pubmed-meshheading:11703588-Enzyme Activation,
pubmed-meshheading:11703588-Glomerular Mesangium,
pubmed-meshheading:11703588-MAP Kinase Kinase 1,
pubmed-meshheading:11703588-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:11703588-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:11703588-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11703588-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11703588-Pressure,
pubmed-meshheading:11703588-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11703588-RNA, Messenger,
pubmed-meshheading:11703588-Rats,
pubmed-meshheading:11703588-Rats, Wistar
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pubmed:year |
2001
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pubmed:articleTitle |
Pressure-induced expression of monocyte chemoattractant protein-1 through activation of MAP kinase.
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pubmed:affiliation |
The Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahatanishi, Kitakyushu 807-8555, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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