rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-11-12
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pubmed:abstractText |
Secondary hyperparathyroidism (HPT) is characterized by inappropriate control of parathyroid hormone (PTH) secretion and asymmetric hyperplasia of the parathyroid glands. Receptors for calcium and vitamin D are involved in the control of secretion, as well as parathyroid cell proliferation. Defective receptor mechanisms therefore may play a role in the pathogenensis of secondary HPT. Previous studies have shown that the expression of calcium receptor (CaR), calcium-sensing receptor (CAS) and vitamin D receptor (VDR) protein, and mRNA is decreased in hyperplastic parathyroid glands of secondary HPT when compared with normal parathyroid glands.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glyceraldehyde-3-Phosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcium-Sensing,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1666-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11703583-Adult,
pubmed-meshheading:11703583-Aged,
pubmed-meshheading:11703583-Calcium-Binding Proteins,
pubmed-meshheading:11703583-Child,
pubmed-meshheading:11703583-Female,
pubmed-meshheading:11703583-Glyceraldehyde-3-Phosphate Dehydrogenases,
pubmed-meshheading:11703583-Humans,
pubmed-meshheading:11703583-Hyperparathyroidism, Secondary,
pubmed-meshheading:11703583-Male,
pubmed-meshheading:11703583-Middle Aged,
pubmed-meshheading:11703583-Parathyroid Glands,
pubmed-meshheading:11703583-Parathyroid Hormone,
pubmed-meshheading:11703583-RNA, Messenger,
pubmed-meshheading:11703583-Receptors, Calcitriol,
pubmed-meshheading:11703583-Receptors, Calcium-Sensing,
pubmed-meshheading:11703583-Receptors, Cell Surface
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pubmed:year |
2001
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pubmed:articleTitle |
Heterogeneous expression of receptor mRNAs in parathyroid glands of secondary hyperparathyroidism.
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pubmed:affiliation |
Department of Molecular Medicine, Endocrine Tumor Unit, CMM L8:01, Karolinska Hospital, S-171 76 Stockholm, Sweden. Stiina.Valimaki@cmm.ki.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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