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rdf:type |
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lifeskim:mentions |
umls-concept:C0005767,
umls-concept:C0012634,
umls-concept:C0030705,
umls-concept:C0033860,
umls-concept:C0039194,
umls-concept:C0050156,
umls-concept:C0085358,
umls-concept:C0376249,
umls-concept:C0439793,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
2
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pubmed:dateCreated |
2001-11-12
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pubmed:abstractText |
Psoriasis is thought to be a T cell-mediated skin disease and the cutaneous lymphocyte antigen (CLA) is an important skin homing epitope for T cells. We have studied the relationship between disease severity (PASI) and phenotypic analysis of T cells in the blood of 36 patients with psoriasis focusing on the expression of CLA, VLA-4 and CD25 on CD4+ and CD8+ T cells. The patients had a higher frequency of circulating CLA+ CD8+ cells than healthy controls. Furthermore, a much stronger correlation was observed between PASI and the frequency of CLA+ CD8+ than CLA+ CD4+ T cells. The frequency of CLA+D8+ T cells correlated more strongly with redness, thickness and scaling of the skin lesions than the total affected body surface area. In contrast to CLA the T cell expression of VLA-4 did not demonstrate any such correlation. Finally, the expression of the activation marker CD25 on CD8+ T cells showed a strong correlation with disease severity in patients with moderate to severe psoriasis (PASI > 10) but such correlation was not observed for CD4+ T cells. These findings support the notion that circulating CLA+ CD8+ T cells may play an important role in the pathogenesis of psoriasis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-10233646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-10328195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-10343943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-10354020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-10393847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-10545511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-10648117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-10951148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-10954208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-11084303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-1607407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-1671837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-1700003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-1705666,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-357213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-6229268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-7387872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-7537129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-7678617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-7718088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-7914525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-8342960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-8546722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-8587600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-8666674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-8818183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-8891007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-8941229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-8953411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-9284091,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-9353122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703383-9498161
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
365-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11703383-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:11703383-Antigens, Neoplasm,
pubmed-meshheading:11703383-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11703383-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11703383-Case-Control Studies,
pubmed-meshheading:11703383-Humans,
pubmed-meshheading:11703383-Membrane Glycoproteins,
pubmed-meshheading:11703383-Psoriasis,
pubmed-meshheading:11703383-Receptors, Interleukin-2,
pubmed-meshheading:11703383-T-Lymphocyte Subsets
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pubmed:year |
2001
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pubmed:articleTitle |
The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlates closely with the severity of their disease.
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pubmed:affiliation |
Department of Immunology, Landspítali University Hospital, Reykjavík, Iceland.
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pubmed:publicationType |
Journal Article
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