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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-11-12
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pubmed:abstractText |
Although increased expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) has been demonstrated in inflammatory sites of various diseases, its role in colitis remains unknown. In this study, we examined whether MAdCAM-1 is involved in the pathogenesis of granulomatous colitis induced by peptidoglycan-polysaccharide (PG-PS). Experimental colitis was induced by intramural injection of PG-PS to rat colon. After 3 weeks the colon was removed and the mucosal inflammation was assessed. The area of MAdCAM-1-positive venules and the subsets of infiltrating cells were determined in colonic mucosa by immunohistochemistry. In another experiment, monoclonal antibody against MAdCAM-1 was administered intraperitoneally to examine its attenuating effect on colitis. The intramural injection of PG-PS induced significant colonic inflammation with granuloma formation. The submucosa was drastically thickened with the infiltration of CD4 positive lymphocytes and ED-1 positive macrophages. Intense MAdCAM-1 expression was observed on endothelium of the submucosal venules in inflamed mucosa. Administration of anti-MAdCAM-1 antibody significantly attenuated the PG-PS-induced colonic damage and cell infiltration. Enhanced expression of MAdCAM-1 was demonstrated in venular endothelium of the inflamed colon in PG-PS-induced colitis. The attenuating effect of anti-MAdCAM-1 suggests the importance of the MAdCAM-1-dependent process in the formation of chronic granulomatous colitis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-10080539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-10562584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-10679083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-10991977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-11045571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-1648926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-3876354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-7511642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-7546210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-7680014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-7687523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-7693807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-8299918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-8406849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-8600538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-8613052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-8770044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-8898653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-8912000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-9036954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-9038666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11703369-9212736
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0009-9104
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pubmed:author |
pubmed-author:HokariRR,
pubmed-author:IizukaTT,
pubmed-author:IshiiHH,
pubmed-author:ItohKK,
pubmed-author:IwaiAA,
pubmed-author:KatoSS,
pubmed-author:KawaguchiAA,
pubmed-author:MatsuzakiKK,
pubmed-author:MiuraSS,
pubmed-author:MiyaharaTT,
pubmed-author:MiyasakaMM,
pubmed-author:NagaoSS,
pubmed-author:NagataHH,
pubmed-author:SekizukaEE
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-65
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11703369-Animals,
pubmed-meshheading:11703369-Antibodies, Monoclonal,
pubmed-meshheading:11703369-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11703369-Cell Adhesion Molecules,
pubmed-meshheading:11703369-Cell Movement,
pubmed-meshheading:11703369-Chronic Disease,
pubmed-meshheading:11703369-Crohn Disease,
pubmed-meshheading:11703369-Endothelium, Vascular,
pubmed-meshheading:11703369-Female,
pubmed-meshheading:11703369-Immunoglobulins,
pubmed-meshheading:11703369-Immunohistochemistry,
pubmed-meshheading:11703369-Intestinal Mucosa,
pubmed-meshheading:11703369-Mucoproteins,
pubmed-meshheading:11703369-Peptidoglycan,
pubmed-meshheading:11703369-Polysaccharides,
pubmed-meshheading:11703369-Rats,
pubmed-meshheading:11703369-Rats, Inbred Lew
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pubmed:year |
2001
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pubmed:articleTitle |
Involvement of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the pathogenesis of granulomatous colitis in rats.
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pubmed:affiliation |
Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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