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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-11-12
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pubmed:abstractText |
Oocytes are released from meiotic prophase I arrest through a process termed oocyte maturation. We present here a genetic characterization of oocyte maturation, using C. elegans as a model system. We show that two TIS11 zinc finger-containing proteins, OMA-1 and OMA-2, express specifically in maturing oocytes and function redundantly in oocyte maturation. Oocytes in oma-1;oma-2 mutants initiate but do not complete maturation and arrest at a defined point in prophase I. Two maturation signal-induced molecular events, including the maintenance of activated MAP kinase, do not occur in Oma oocytes. The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1534-5807
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-99
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11702779-Alleles,
pubmed-meshheading:11702779-Amino Acid Sequence,
pubmed-meshheading:11702779-Animals,
pubmed-meshheading:11702779-Blotting, Western,
pubmed-meshheading:11702779-Caenorhabditis elegans,
pubmed-meshheading:11702779-Caenorhabditis elegans Proteins,
pubmed-meshheading:11702779-Carrier Proteins,
pubmed-meshheading:11702779-Escherichia coli,
pubmed-meshheading:11702779-Female,
pubmed-meshheading:11702779-Infertility, Female,
pubmed-meshheading:11702779-Infertility, Male,
pubmed-meshheading:11702779-Male,
pubmed-meshheading:11702779-Microscopy, Fluorescence,
pubmed-meshheading:11702779-Models, Biological,
pubmed-meshheading:11702779-Molecular Sequence Data,
pubmed-meshheading:11702779-Mutation,
pubmed-meshheading:11702779-Oocytes,
pubmed-meshheading:11702779-Prophase,
pubmed-meshheading:11702779-Protein Binding,
pubmed-meshheading:11702779-RNA,
pubmed-meshheading:11702779-RNA, Bacterial,
pubmed-meshheading:11702779-Sequence Homology, Amino Acid,
pubmed-meshheading:11702779-Sex Factors,
pubmed-meshheading:11702779-Signal Transduction,
pubmed-meshheading:11702779-Spermatozoa,
pubmed-meshheading:11702779-Zinc Fingers
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pubmed:year |
2001
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pubmed:articleTitle |
Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans.
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pubmed:affiliation |
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390-9148, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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