Linked Life Data

11702199

Source:http://linkedlifedata.com/resource/pubmed/id/11702199

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-11-9
pubmed:databankReference
pubmed:abstractText
A number of genes that are involved in somitogenesis in vertebrates are cyclically expressed in the presomitic mesoderm. These include homologues of the Drosophila genes fringe and hairy. We have analysed here two genes that belong to these classes in the zebrafish, namely the apparent orthologues of lunatic fringe (l-fng) and of c-hairy1 (called her9). However, unlike the respective mouse and chicken genes, they are not expressed cyclically in the presomitic mesoderm. Instead, both genes are mainly expressed in the central nervous system. her9 is predominantly expressed in the fore- and midbrain, and transiently in the hindbrain. Thus, the previously identified and only very distantly related her1 gene of zebrafish has more similarities to the expression of the c-hairy1 gene than its apparent orthologue her9, indicating that sequence similarity and similarity of function are not necessarily linked in this case. l-fng expression is found in alternating pre-rhombomeres, comparable to the equivalent mouse gene expression and in the anterior compartments of the mature somites, which was also shown for the chicken l-fng gene. The latter expression indicates that it might be involved in boundary definition and cell fate decision processes, rather than in pre-patterning of the somites. Interestingly, a similar role has previously been inferred for the grasshopper homologue of l-fng. This suggests that the function of l-fng in boundary definition of the somites might be ancestral, while its recruitment to the pre-patterning process of the somites might be a derived feature in higher vertebrates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0949-944X
pubmed:author
pubmed:issnType
Print
pubmed:volume
211
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
493-500
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11702199-Amino Acid Sequence, pubmed-meshheading:11702199-Animals, pubmed-meshheading:11702199-Basic Helix-Loop-Helix Transcription Factors, pubmed-meshheading:11702199-Central Nervous System, pubmed-meshheading:11702199-Cloning, Molecular, pubmed-meshheading:11702199-Gene Expression Profiling, pubmed-meshheading:11702199-Gene Expression Regulation, Developmental, pubmed-meshheading:11702199-Glycosyltransferases, pubmed-meshheading:11702199-In Situ Hybridization, pubmed-meshheading:11702199-Mesoderm, pubmed-meshheading:11702199-Molecular Sequence Data, pubmed-meshheading:11702199-Phylogeny, pubmed-meshheading:11702199-Proteins, pubmed-meshheading:11702199-RNA, Messenger, pubmed-meshheading:11702199-Sequence Homology, Amino Acid, pubmed-meshheading:11702199-Somites, pubmed-meshheading:11702199-Zebrafish, pubmed-meshheading:11702199-Zebrafish Proteins
pubmed:year
2001
pubmed:articleTitle
Homologues of c-hairy1 (her9) and lunatic fringe in zebrafish are expressed in the developing central nervous system, but not in the presomitic mesoderm.
pubmed:affiliation
Universität zu Köln, Institut für Genetik, Weyertal 121, 50931 Cologne, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't