|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2001-11-28
|
|
pubmed:abstractText |
Activation of dendritic cells (DCs) and macrophages by infectious agents leads to secretion of interleukin 12 (IL-12), which subsequently induces interferon-gamma (IFN-gamma) production by multiple cell types that include DCs and macrophages. In turn, IFN-gamma acts on macrophages to augment IL-12 secretion and to produce nitric oxide (NO), which eradicates infected microbes. We show here that in cytokine common gamma subunit-deficient and/or IL-2 receptor beta-deficient mice, production of IL-12, IFN-gamma and NO by DCs and macrophages was severely impaired, as was up-regulation of major histocompatibility complex class II and CD40. Similar phenotypes were observed in DCs and macrophages from IL-15-deficient mice but not in those from IL-2-deficient mice. This shows that the IL-15-IL-15R interaction is critical in early activation of antigen-presenting cells and plays an important role in the innate immune system.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD40,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Il15ra protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Il2rb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor beta Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1529-2908
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1138-43
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:11702064-Animals,
pubmed-meshheading:11702064-Antigens, CD40,
pubmed-meshheading:11702064-Cells, Cultured,
pubmed-meshheading:11702064-Dendritic Cells,
pubmed-meshheading:11702064-Histocompatibility Antigens Class II,
pubmed-meshheading:11702064-Interferon-gamma,
pubmed-meshheading:11702064-Interleukin-12,
pubmed-meshheading:11702064-Interleukin-15,
pubmed-meshheading:11702064-Interleukin-2,
pubmed-meshheading:11702064-Interleukin-2 Receptor beta Subunit,
pubmed-meshheading:11702064-Macrophages,
pubmed-meshheading:11702064-Mice,
pubmed-meshheading:11702064-Mice, Inbred C57BL,
pubmed-meshheading:11702064-Mice, Knockout,
pubmed-meshheading:11702064-Nitric Oxide,
pubmed-meshheading:11702064-RNA, Messenger,
pubmed-meshheading:11702064-Receptors, Interleukin,
pubmed-meshheading:11702064-Receptors, Interleukin-15,
pubmed-meshheading:11702064-Receptors, Interleukin-2,
pubmed-meshheading:11702064-Up-Regulation
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response.
|
|
pubmed:affiliation |
Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
