Source:http://linkedlifedata.com/resource/pubmed/id/11702051
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2001-11-19
|
| pubmed:abstractText |
Genetic factors, such as the genes involved in the serotonin pathway, probably play an important role in the pathogenesis of bipolar disorder, and serotonin type 2A (5-HT2A) receptor gene promoter polymorphism -1438A/G has been reported. This study investigated the association between -1438A/G polymorphism of 5-HT2A receptor gene promoter and bipolar disorder in a Korean population. Using the polymerase chain reaction, -1438A/G polymorphism typed in 142 patients with bipolar disorder and in 148 normal control subjects. Differences in genotype distributions and allele frequencies of -1438A/G between patients with bipolar disorder and normal control subjects were tested for significance using the chi-squared test. There were significant differences in genotype distributions [chi2 = 9.697, degrees of freedom (df) = 2, P = 0.008] and allele frequencies (chi2 = 7.284, df = 1, P = 0.007) of -1438A/G between patients with bipolar disorder and normal control subjects. Although further studies are necessary, these results in a Korean population suggest that -1438A/G polymorphism of 5-HT2A receptor gene promoter may be causally related to the development of bipolar disorder.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0955-8829
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
111-4
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11702051-Adenine,
pubmed-meshheading:11702051-Adult,
pubmed-meshheading:11702051-Asian Continental Ancestry Group,
pubmed-meshheading:11702051-Bipolar Disorder,
pubmed-meshheading:11702051-Chi-Square Distribution,
pubmed-meshheading:11702051-Female,
pubmed-meshheading:11702051-Gene Frequency,
pubmed-meshheading:11702051-Genotype,
pubmed-meshheading:11702051-Guanine,
pubmed-meshheading:11702051-Humans,
pubmed-meshheading:11702051-Korea,
pubmed-meshheading:11702051-Male,
pubmed-meshheading:11702051-Polymerase Chain Reaction,
pubmed-meshheading:11702051-Polymorphism, Genetic,
pubmed-meshheading:11702051-Promoter Regions, Genetic,
pubmed-meshheading:11702051-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:11702051-Receptors, Serotonin,
pubmed-meshheading:11702051-Reference Values
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder.
|
| pubmed:affiliation |
Department of Psychiatry, Chungnam National University Hospital, College of Medicine, Chungnam National University, Jung-Ku, Taejon, Korea. ischee@cnu.ac.kr
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| pubmed:publicationType |
Journal Article,
Comparative Study
|