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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5551
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pubmed:dateCreated |
2001-12-25
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pubmed:abstractText |
We describe a molecular switch based on the controlled methylation of nucleosome and the transcriptional cofactors, the CREB-binding proteins (CBP)/p300. The CBP/p300 methylation site is localized to an arginine residue that is essential for stabilizing the structure of the KIX domain, which mediates CREB recruitment. Methylation of KIX by coactivator-associated arginine methyltransferase 1 (CARM1) blocks CREB activation by disabling the interaction between KIX and the kinase inducible domain (KID) of CREB. Thus, CARM1 functions as a corepressor in cyclic adenosine monophosphate signaling pathway via its methyltransferase activity while acting as a coactivator for nuclear hormones. These results provide strong in vivo and in vitro evidence that histone methylation plays a key role in hormone-induced gene activation and define cofactor methylation as a new regulatory mechanism in hormone signaling.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/E1A-Associated p300 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Ep300 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Histones,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Arginine...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoid X Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/coactivator-associated arginine...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
294
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2507-11
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11701890-Acetyltransferases,
pubmed-meshheading:11701890-Amino Acid Sequence,
pubmed-meshheading:11701890-Animals,
pubmed-meshheading:11701890-Apoptosis,
pubmed-meshheading:11701890-Cell Line,
pubmed-meshheading:11701890-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:11701890-Dimerization,
pubmed-meshheading:11701890-E1A-Associated p300 Protein,
pubmed-meshheading:11701890-Gene Expression Regulation,
pubmed-meshheading:11701890-Genes, Reporter,
pubmed-meshheading:11701890-Histone Acetyltransferases,
pubmed-meshheading:11701890-Histones,
pubmed-meshheading:11701890-Methylation,
pubmed-meshheading:11701890-Molecular Sequence Data,
pubmed-meshheading:11701890-Nerve Growth Factor,
pubmed-meshheading:11701890-Nuclear Proteins,
pubmed-meshheading:11701890-PC12 Cells,
pubmed-meshheading:11701890-Protein Structure, Tertiary,
pubmed-meshheading:11701890-Protein-Arginine N-Methyltransferases,
pubmed-meshheading:11701890-Rats,
pubmed-meshheading:11701890-Receptors, Retinoic Acid,
pubmed-meshheading:11701890-Recombinant Fusion Proteins,
pubmed-meshheading:11701890-Retinoid X Receptors,
pubmed-meshheading:11701890-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:11701890-Signal Transduction,
pubmed-meshheading:11701890-Somatostatin,
pubmed-meshheading:11701890-Trans-Activators,
pubmed-meshheading:11701890-Transcription, Genetic,
pubmed-meshheading:11701890-Transcription Factors,
pubmed-meshheading:11701890-Transcriptional Activation,
pubmed-meshheading:11701890-Transfection,
pubmed-meshheading:11701890-Tretinoin
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pubmed:year |
2001
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pubmed:articleTitle |
A transcriptional switch mediated by cofactor methylation.
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pubmed:affiliation |
Gene Expression Laboratory, Department of Biological Chemistry, University of California Davis Cancer Center/Basic Science, Sacramento, CA 95817, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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