Linked Life Data

11701705

Source:http://linkedlifedata.com/resource/pubmed/id/11701705

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-11-9
pubmed:abstractText
To determine the effect of hyperthyroidism on hepatic lipogenesis and cholesterol synthesis we measured these metabolic pathways (deuterated water method) in euthyroid and hyperthyroid subjects investigated in the postabsorptive state. Hyperthyroid patients had increased concentrations of glucose (P < 0.05), insulin (P < 0.05), nonesterified fatty acids (P < 0.01), and triglycerides (P < 0.05) and decreased levels of plasma cholesterol (P < 0.01). The contribution of hepatic lipogenesis to plasma triglycerides was largely increased in hyperthyroid subjects (23.0 +/- 1.8% vs. 7.5 +/- 0.2%; P < 0.001), whereas the fractional synthetic rate of cholesterol was moderately higher (5.0 +/- 0.8% vs. 3.3 +/- 0.2%; P < 0.05). mRNA levels of beta-hydroxy-beta-methyl glutaryl-coenzyme A reductase, measured in circulating mononuclear cells, were increased (P < 0.05), whereas those of low density lipoprotein (LDL) receptor and LDL receptor-related protein were unchanged. Sterol responsive element binding protein-1c mRNAs were undetectable in mononuclear cells from both groups of subjects. The large stimulation of hepatic lipogenesis in hyperthyroid patients is probably explained by both a direct action of thyroid hormones and the increase in insulin. It could contribute to their moderate rise in triglycerides levels. The decreased plasma cholesterol level is observed despite an enhanced synthetic rate and is thus related to an increased clearance rate. The lack of increased expression of LDL receptor and LDL receptor-related protein suggests that other receptors are implicated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5353-7
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:11701705-Adult, pubmed-meshheading:11701705-CCAAT-Enhancer-Binding Proteins, pubmed-meshheading:11701705-Cholesterol, pubmed-meshheading:11701705-DNA-Binding Proteins, pubmed-meshheading:11701705-Female, pubmed-meshheading:11701705-Graves Disease, pubmed-meshheading:11701705-Hepatocytes, pubmed-meshheading:11701705-Humans, pubmed-meshheading:11701705-Hydroxymethylglutaryl CoA Reductases, pubmed-meshheading:11701705-Hyperthyroidism, pubmed-meshheading:11701705-Lipids, pubmed-meshheading:11701705-Liver, pubmed-meshheading:11701705-Male, pubmed-meshheading:11701705-Monocytes, pubmed-meshheading:11701705-RNA, Messenger, pubmed-meshheading:11701705-Receptors, LDL, pubmed-meshheading:11701705-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:11701705-Sterol Regulatory Element Binding Protein 1, pubmed-meshheading:11701705-Transcription Factors
pubmed:year
2001
pubmed:articleTitle
Hepatic lipogenesis and cholesterol synthesis in hyperthyroid patients.
pubmed:affiliation
INSERM, U-499, and Genalys, Université R. T. H. Laennec, Laboratoire de Biochimie, Hôpital E. Herriot, Centre de Recherche en Nutrition Humaine, Hôpital E. Herriot, 69008 Lyon, France.
pubmed:publicationType
Journal Article, Clinical Trial