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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-11-8
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pubmed:abstractText |
We designed the present study to elucidate the molecular mechanism for parturition, focusing on p38 mitogen-activated protein kinase (p38). The kinase activity of p38 in mouse uterus was gestation stage-dependent, and was markedly increased on day 19 of gestation and during labor. Immunohistochemical examination with anti-phospho p38 antibody revealed that activated p38 was predominantly localized in decidual stromal cells stained with anti-prolactin antibody. In human primary cultured decidual cells, a p38 inhibitor, SB202190, significantly inhibited both prostaglandin F(2alpha) production and COX-2 expression induced by stimulation with IL-1beta. These results suggest that the p38 signaling pathway is involved in decidual function at the late stage of gestation and may contribute to parturition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(4-fluorophenyl)-2-(4-hydroxypheny...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprost,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1155-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11700032-Animals,
pubmed-meshheading:11700032-Cells, Cultured,
pubmed-meshheading:11700032-Cyclooxygenase 2,
pubmed-meshheading:11700032-Decidua,
pubmed-meshheading:11700032-Dinoprost,
pubmed-meshheading:11700032-Female,
pubmed-meshheading:11700032-Humans,
pubmed-meshheading:11700032-Imidazoles,
pubmed-meshheading:11700032-Immunohistochemistry,
pubmed-meshheading:11700032-Isoenzymes,
pubmed-meshheading:11700032-Kinetics,
pubmed-meshheading:11700032-Labor, Obstetric,
pubmed-meshheading:11700032-Membrane Proteins,
pubmed-meshheading:11700032-Mice,
pubmed-meshheading:11700032-Mice, Inbred C57BL,
pubmed-meshheading:11700032-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11700032-Pregnancy,
pubmed-meshheading:11700032-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:11700032-Pyridines,
pubmed-meshheading:11700032-Uterus,
pubmed-meshheading:11700032-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2001
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pubmed:articleTitle |
Possible involvement of p38 mitogen-activated protein kinase in decidual function in parturition.
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pubmed:affiliation |
Department of Biochemistry and Molecular Pharmacology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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