|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2001-11-8
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|
pubmed:abstractText |
Adenoviral vectors are promising gene transfer vehicles for different gene therapy applications. High-capacity adenoviral (HC-Ad) vectors address some of the problems that have been observed with replication-defective, E1-deleted first-generation adenoviral vectors: toxicity and immunogenicity due to viral gene expression and 7 to 8 kb capacity limit for the transport of therapeutic DNA. This review summarizes HC-Ad vector-related publications from the past 18 months that are mainly concerned with vector design/production and in vivo applications in different murine models.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1464-8431
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
3
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
454-63
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|
pubmed:dateRevised |
2006-4-21
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|
pubmed:meshHeading |
pubmed-meshheading:11699889-Adenoviridae,
pubmed-meshheading:11699889-Animals,
pubmed-meshheading:11699889-Capsid,
pubmed-meshheading:11699889-Central Nervous System,
pubmed-meshheading:11699889-DNA, Recombinant,
pubmed-meshheading:11699889-Gene Expression,
pubmed-meshheading:11699889-Gene Therapy,
pubmed-meshheading:11699889-Gene Transfer Techniques,
pubmed-meshheading:11699889-Genetic Techniques,
pubmed-meshheading:11699889-Genetic Vectors,
pubmed-meshheading:11699889-Genome, Viral,
pubmed-meshheading:11699889-Humans,
pubmed-meshheading:11699889-Liver,
pubmed-meshheading:11699889-Mice,
pubmed-meshheading:11699889-Muscle, Skeletal,
pubmed-meshheading:11699889-Virus Integration
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
High-capacity 'gutless' adenoviral vectors.
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|
pubmed:affiliation |
Center for Molecular Medicine, University of Cologne, Germany. Stefan.Kochanek@medizin.uni-koeln.de
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pubmed:publicationType |
Journal Article,
Review
|
