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pubmed-article:11699610pubmed:abstractTextWe previously found that, compared with healthy subjects. asymptomatic hepatitis-B virus (HBV) carriers displaying slow acetylator phenotype demonstrate a significant prolongation of the elimination half-life of 4-methylaminoantipyrine (MAA) and a decrease in the clearance of formation of 4-aminoantipyrine (AA) and 4-formylaminoantipyrine (FAA). However, the formation of 4-acetylaminoantipyrine (AAA) was unchanged. The present study was designed to examine the effect of the asymptomatic HBV carrier state on the metabolism of dipyrone. as a model drug, in rapid acetylators.lld:pubmed
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pubmed-article:11699610pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11699610pubmed:articleTitleImpairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.lld:pubmed
pubmed-article:11699610pubmed:affiliationDepartment of Medicine, Hadassah University Hospital, Jerusalem, Israel. mlevy@md.huji.ac.illld:pubmed
pubmed-article:11699610pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11699610pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:11699610pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed