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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6-7
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pubmed:dateCreated |
2001-11-8
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pubmed:abstractText |
We previously found that, compared with healthy subjects. asymptomatic hepatitis-B virus (HBV) carriers displaying slow acetylator phenotype demonstrate a significant prolongation of the elimination half-life of 4-methylaminoantipyrine (MAA) and a decrease in the clearance of formation of 4-aminoantipyrine (AA) and 4-formylaminoantipyrine (FAA). However, the formation of 4-acetylaminoantipyrine (AAA) was unchanged. The present study was designed to examine the effect of the asymptomatic HBV carrier state on the metabolism of dipyrone. as a model drug, in rapid acetylators.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0031-6970
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
461-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11699610-Acetylation,
pubmed-meshheading:11699610-Adult,
pubmed-meshheading:11699610-Algorithms,
pubmed-meshheading:11699610-Aminopyrine,
pubmed-meshheading:11699610-Ampyrone,
pubmed-meshheading:11699610-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11699610-Area Under Curve,
pubmed-meshheading:11699610-Carrier State,
pubmed-meshheading:11699610-Dipyrone,
pubmed-meshheading:11699610-Female,
pubmed-meshheading:11699610-Half-Life,
pubmed-meshheading:11699610-Hepatitis B virus,
pubmed-meshheading:11699610-Humans,
pubmed-meshheading:11699610-Male,
pubmed-meshheading:11699610-Metabolic Clearance Rate,
pubmed-meshheading:11699610-Models, Biological,
pubmed-meshheading:11699610-Pyrazolones
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pubmed:year |
2001
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pubmed:articleTitle |
Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators.
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pubmed:affiliation |
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel. mlevy@md.huji.ac.il
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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