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rdf:type |
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lifeskim:mentions |
umls-concept:C0006434,
umls-concept:C0033684,
umls-concept:C0034693,
umls-concept:C0038435,
umls-concept:C0040661,
umls-concept:C0205548,
umls-concept:C0312431,
umls-concept:C0699819,
umls-concept:C0805732,
umls-concept:C1335960,
umls-concept:C1366753,
umls-concept:C1548425,
umls-concept:C1705162,
umls-concept:C1710082
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pubmed:issue |
5
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pubmed:dateCreated |
2001-11-8
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pubmed:abstractText |
A burn injury triggers traumatic reactions characteristics of a stress. Here we investigated the early responses of prolactin (PRL), corticosterone (CS), and signal transducer and activator of transcription 5 (STAT5) in male Sprague-Dawley rats after burn injury. PRL and CS levels were determined in blood serum. STAT5 and phospho-STAT5 levels were determined in jejunum total protein extracts. The results confirmed an expected increase of CS between 4 and 6 h after the burn injury. Unexpectedly, PRL secretion was suppressed during the same time frame. These hormone levels returned to normal 6 to 8 h after burn injury. STAT5 was increased in the jejunum after burn injury, and its phosphorylation was increased between 8 and 11 h after burn injury. These changes in STAT5 were not temporally correlated with either the hormone changes that we observed or with previously documented changes of the gut function after burns.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1073-2322
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
393-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11699080-Adrenocorticotropic Hormone,
pubmed-meshheading:11699080-Animals,
pubmed-meshheading:11699080-Burns,
pubmed-meshheading:11699080-CHO Cells,
pubmed-meshheading:11699080-Circadian Rhythm,
pubmed-meshheading:11699080-Corticosterone,
pubmed-meshheading:11699080-Cricetinae,
pubmed-meshheading:11699080-DNA-Binding Proteins,
pubmed-meshheading:11699080-Growth Hormone,
pubmed-meshheading:11699080-Jejunum,
pubmed-meshheading:11699080-Macrophages,
pubmed-meshheading:11699080-Milk Proteins,
pubmed-meshheading:11699080-Monocytes,
pubmed-meshheading:11699080-Phosphorylation,
pubmed-meshheading:11699080-Prolactin,
pubmed-meshheading:11699080-Rats,
pubmed-meshheading:11699080-STAT5 Transcription Factor,
pubmed-meshheading:11699080-Signal Transduction,
pubmed-meshheading:11699080-Stress, Physiological,
pubmed-meshheading:11699080-Trans-Activators
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pubmed:year |
2001
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pubmed:articleTitle |
Stress hormone secretion and gut signal transducer (STAT) proteins after burn injury in rats.
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pubmed:affiliation |
Department of Molecular and Cellular Physiology, University of Cincinnati, 231 Bethesda Avenue, Cincinnati, OH 45267-0576, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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