Source:http://linkedlifedata.com/resource/pubmed/id/11699055
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2001-11-7
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| pubmed:abstractText |
To investigate the genetic susceptibility associated with cough related to angiotensin-converting enzyme inhibitor (ACEI) therapy in patients with type 2 diabetes, 189 non-insulin-dependent diabetes mellitus (NIDDM) patients with proteinuria or hypertension treated with perindopril were studied. Cough was considered to be present if the patients had been bothered by a cough during treatment and if they had had related symptoms for at least 2 weeks without an identifiable cause. Polymerase chain reaction (PCR) coupled with single-strand conformation polymorphism (SSCP) was used to detect polymorphisms of ACE and bradykinin B2-receptor genes. After 8 weeks of treatment, 49.2% (93 of 189) of our NIDDM patients were found to be suffering from ACEI-related cough. ACEI-related cough was mainly associated with female patients, with 71.7% (76 of 106) of female and only 20.5% (17 of 83) of male patients experiencing cough after ACEI treatment. There was a significant association of ACE II genotype with ACEI-related cough. The genotype frequencies were 58.2% for II, 47.8% for ID, and 16.7% for DD in patients with ACEI-associated cough and 41.8% for II, 52.2% for ID, and 83.3% for DD in subjects without ACEI-associated cough (chi(2) = 10.268; df = 2, P =.006). As female patients made up the majority of the subjects suffering from ACEI-related cough, we further analyzed the association of ACE I/D genotype with ACEI-related cough separately by sex. Male patients with ACEI-related cough were not associated with ACE I/D genotype distribution, while female patients were strongly associated with ACE I/D genotype polymorphism (chi(2) = 16.12; df = 2; P <.001). There was no association between the bradykinin B2 receptor gene -58T/C polymorphism with ACEI-related cough. In conclusion, our results indicate that Chinese diabetic female subjects are susceptible to ACEI-related cough, and this susceptibility may be genetically predetermined.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/Perindopril,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Bradykinin B2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Bradykinin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0026-0495
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 by W.B. Saunders Company
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| pubmed:issnType |
Print
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| pubmed:volume |
50
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1346-50
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11699055-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:11699055-Case-Control Studies,
pubmed-meshheading:11699055-Comorbidity,
pubmed-meshheading:11699055-Cough,
pubmed-meshheading:11699055-Diabetes Mellitus, Type 2,
pubmed-meshheading:11699055-Female,
pubmed-meshheading:11699055-Genetic Predisposition to Disease,
pubmed-meshheading:11699055-Genotype,
pubmed-meshheading:11699055-Humans,
pubmed-meshheading:11699055-Hypertension,
pubmed-meshheading:11699055-Male,
pubmed-meshheading:11699055-Middle Aged,
pubmed-meshheading:11699055-Peptidyl-Dipeptidase A,
pubmed-meshheading:11699055-Perindopril,
pubmed-meshheading:11699055-Polymerase Chain Reaction,
pubmed-meshheading:11699055-Polymorphism, Genetic,
pubmed-meshheading:11699055-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:11699055-Prevalence,
pubmed-meshheading:11699055-Proteinuria,
pubmed-meshheading:11699055-Receptor, Bradykinin B2,
pubmed-meshheading:11699055-Receptors, Bradykinin,
pubmed-meshheading:11699055-Sex Distribution,
pubmed-meshheading:11699055-Taiwan
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| pubmed:year |
2001
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| pubmed:articleTitle |
Angiotensin-converting enzyme gene insertion/deletion, not bradykinin B2 receptor -58T/C gene polymorphism, associated with angiotensin-converting enzyme inhibitor-related cough in Chinese female patients with non-insulin-dependent diabetes mellitus.
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| pubmed:affiliation |
Department of Clinical Research, Ping-Tung Christian Hospital, Ping-Tung, Taiwan, Republic of China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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