Linked Life Data

11699046

Source:http://linkedlifedata.com/resource/pubmed/id/11699046

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-11-7
pubmed:abstractText
The aim of this study was to examine the role of fasting insulin concentrations and tissue insulin sensitivity on whole-body substrate oxidation in 61 well-trained subjects. Subjects underwent a frequently sampled intravenous glucose tolerance test (FSIVGT) after a 10- to 12-hour overnight fast. Minimal model analysis was used to determine insulin sensitivity (S(i)). A week later, fasting (10- to 12-hour) respiratory exchange ratio (RER) was measured at rest and during exercise at 25%, 50%, and 70% of peak power output (W(peak)). Prior to these measurements, training volume, dietary intake, and muscle fiber composition, substrate concentrations, and enzyme activities were determined. The average fasting plasma insulin concentration was 7.3 +/- 2.4 microU/mL (4.0 to 10.5 microU/mL), and the mean S(i) was 14.0 +/- 6.1 x (10(-4) min(-1) x microU(-1) x mL(-1)) (2.6 to 26.3 x 10(-4) min(-1) x microU(-1) x mL(-1)). There was no significant correlation between fasting plasma insulin concentration and S(i) (r = -.14, P =.336) or between these measurements and fasting RER, measured at rest and during exercise at 25%, 50%, and 70% W(peak). Only VO(2max) and the proportion of type 1 muscle fibers were significantly correlated with S(i) (r =.30, P =.045 and r =.34, P =.026, respectively), and waist-to-hip ratio (WHR) was significantly correlated with fasting plasma insulin concentration (r =.35, P =.006). In conclusion, S(i) and fasting plasma insulin concentration were not associated with fasting RER at rest and during exercise of increasing intensity in trained athletes who have high S(i).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0026-0495
pubmed:author
pubmed:copyrightInfo
Copyright 2001 by W.B. Saunders Company
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1286-93
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Insulin sensitivity measured by the minimal model: no associations with fasting respiratory exchange ratio in trained athletes.
pubmed:affiliation
UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Newlands, South Africa.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't