Linked Life Data

11697752

Source:http://linkedlifedata.com/resource/pubmed/id/11697752

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-11-7
pubmed:abstractText
This study sought to determine effects of multiple dosing of prasterone (DHEA, dehydroepiandrosterone) on the pharmacokinetics of prednisolone and endogenous cortisol secretion. These drugs are likely to be coadministered to patients with systemic lupus erythematosus. Fourteen normal women (ages 30.1 +/- 5.4 years) received single-dose oral prednisone (20 mg) before and after 200 mg/day of oral prasterone for one menstrual cycle (approximately 28 days). Identical assessments, timed to onset of menses, were conducted pretreatment (baseline) and at days 28 and 29 of prasterone treatment and included serum total and free prednisolone, prednisone, DHEA, DHEA-S (dehydroepiandrosterone sulfate), ACTH-stimulated cortisol, and sex hormones and 24-hour urine free cortisol. Pharmacokinetic parameters of prednisolone as assessed by Cmax, t 1/2, AUC, or serum protein binding were not affected by prasterone. The ACTH-stimulated plasma cortisol concentrations were mildly reduced, but 24-hour urinefree cortisol excretion was unchanged during prasterone administration. Serum androstenedione and testosterone increased, while no changes in serum estradiol or estrone occurred. The administration of 200 mg oral prasterone produced serum concentrations of DHEA and DHEA-S significantly greater than endogenous levels. Chronic dosing with 200 mg/day of prasterone did not alter either prednisolone pharmacokinetics or inhibition of cortisol secretion by prednisolone.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0091-2700
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1195-205
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11697752-Adjuvants, Immunologic, pubmed-meshheading:11697752-Administration, Oral, pubmed-meshheading:11697752-Adrenocorticotropic Hormone, pubmed-meshheading:11697752-Adult, pubmed-meshheading:11697752-Algorithms, pubmed-meshheading:11697752-Area Under Curve, pubmed-meshheading:11697752-Circadian Rhythm, pubmed-meshheading:11697752-Cosyntropin, pubmed-meshheading:11697752-Dehydroepiandrosterone, pubmed-meshheading:11697752-Dehydroepiandrosterone Sulfate, pubmed-meshheading:11697752-Drug Interactions, pubmed-meshheading:11697752-Female, pubmed-meshheading:11697752-Glucocorticoids, pubmed-meshheading:11697752-Gonadal Steroid Hormones, pubmed-meshheading:11697752-Humans, pubmed-meshheading:11697752-Hydrocortisone, pubmed-meshheading:11697752-Models, Biological, pubmed-meshheading:11697752-Prednisolone, pubmed-meshheading:11697752-Prednisone
pubmed:year
2001
pubmed:articleTitle
Effects of oral prasterone (dehydroepiandrosterone) on single-dose pharmacokinetics of oral prednisone and cortisol suppression in normal women.
pubmed:affiliation
Department of Pharmaceutical Sciences, School of Pharmacy, State University of New York at Buffalo, 14260, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't