| pubmed-article:11696572 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11696572 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:11696572 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11696572 | lifeskim:mentions | umls-concept:C0022660 | lld:lifeskim |
| pubmed-article:11696572 | lifeskim:mentions | umls-concept:C0475224 | lld:lifeskim |
| pubmed-article:11696572 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11696572 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:11696572 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:11696572 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:11696572 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11696572 | pubmed:dateCreated | 2001-11-6 | lld:pubmed |
| pubmed-article:11696572 | pubmed:abstractText | Leukocytes have been implicated in the pathogenesis of ischemic acute renal failure (ARF), but the roles of the individual cell types involved are largely unknown. Recent indirect evidence suggests that T cells may play an important role in a murine model of ARF. In the current study, we found that mice deficient in T cells (nu/nu mice) are both functionally and structurally protected from postischemic renal injury. Reconstitution of nu/nu mice with wild-type T cells restored postischemic injury. We then analyzed the contribution of the individual T cell subsets to postischemic injury and found that mice deficient in CD4(+) T cells, but not mice deficient in CD8(+) T cells, were significantly protected from ARF. Direct evidence for a pathophysiologic role of the CD4(+) T cell was obtained when reconstitution of CD4-deficient mice with wild-type CD4(+) T cells restored postischemic injury. In addition, adoptive transfers of CD4(+) T cells lacking either the costimulatory molecule CD28 or the ability to produce IFN-gamma were inadequate to restore injury phenotype. These results demonstrate that the CD4(+) T cell is an important mediator of ischemic ARF, and targeting this cell may yield novel therapies. | lld:pubmed |
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| pubmed-article:11696572 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11696572 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11696572 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11696572 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11696572 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11696572 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:11696572 | pubmed:author | pubmed-author:ColvinR BRB | lld:pubmed |
| pubmed-article:11696572 | pubmed:author | pubmed-author:DanielsFF | lld:pubmed |
| pubmed-article:11696572 | pubmed:author | pubmed-author:BuonoP LPL | lld:pubmed |
| pubmed-article:11696572 | pubmed:author | pubmed-author:RabeUU | lld:pubmed |
| pubmed-article:11696572 | pubmed:author | pubmed-author:O'DonnellM... | lld:pubmed |
| pubmed-article:11696572 | pubmed:author | pubmed-author:MauiyyediSS | lld:pubmed |
| pubmed-article:11696572 | pubmed:author | pubmed-author:El GhandourAA | lld:pubmed |
| pubmed-article:11696572 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11696572 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:11696572 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11696572 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11696572 | pubmed:pagination | 1283-90 | lld:pubmed |
| pubmed-article:11696572 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11696572 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11696572 | pubmed:articleTitle | Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. | lld:pubmed |
| pubmed-article:11696572 | pubmed:affiliation | Division of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota, USA. | lld:pubmed |
| pubmed-article:11696572 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11696572 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11696572 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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