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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2001-11-6
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pubmed:abstractText |
Leukocytes have been implicated in the pathogenesis of ischemic acute renal failure (ARF), but the roles of the individual cell types involved are largely unknown. Recent indirect evidence suggests that T cells may play an important role in a murine model of ARF. In the current study, we found that mice deficient in T cells (nu/nu mice) are both functionally and structurally protected from postischemic renal injury. Reconstitution of nu/nu mice with wild-type T cells restored postischemic injury. We then analyzed the contribution of the individual T cell subsets to postischemic injury and found that mice deficient in CD4(+) T cells, but not mice deficient in CD8(+) T cells, were significantly protected from ARF. Direct evidence for a pathophysiologic role of the CD4(+) T cell was obtained when reconstitution of CD4-deficient mice with wild-type CD4(+) T cells restored postischemic injury. In addition, adoptive transfers of CD4(+) T cells lacking either the costimulatory molecule CD28 or the ability to produce IFN-gamma were inadequate to restore injury phenotype. These results demonstrate that the CD4(+) T cell is an important mediator of ischemic ARF, and targeting this cell may yield novel therapies.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-10354265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-10654278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-10708334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-10827152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-11007823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-11053040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-481195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-7609748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-7810691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-7878762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-8613529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-8770173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-9150459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-9169498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-9218504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-9276737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-9399936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-9690039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-9840976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11696572-9853246
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1283-90
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11696572-Acute Kidney Injury,
pubmed-meshheading:11696572-Animals,
pubmed-meshheading:11696572-Antigens, CD28,
pubmed-meshheading:11696572-Antigens, CD4,
pubmed-meshheading:11696572-Antigens, CD8,
pubmed-meshheading:11696572-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11696572-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11696572-Flow Cytometry,
pubmed-meshheading:11696572-Immunohistochemistry,
pubmed-meshheading:11696572-Interferon-gamma,
pubmed-meshheading:11696572-Leukocytes,
pubmed-meshheading:11696572-Macrophages,
pubmed-meshheading:11696572-Mice,
pubmed-meshheading:11696572-Mice, Inbred C57BL,
pubmed-meshheading:11696572-Mice, Knockout,
pubmed-meshheading:11696572-Mice, Nude,
pubmed-meshheading:11696572-Neutrophils,
pubmed-meshheading:11696572-Phenotype,
pubmed-meshheading:11696572-T-Lymphocytes,
pubmed-meshheading:11696572-Time Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure.
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pubmed:affiliation |
Division of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, Minnesota, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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