Source:http://linkedlifedata.com/resource/pubmed/id/11696194
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2001-11-6
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| pubmed:abstractText |
Granulomatous inflammation in schistosomiasis is a delayed-type hypersensitivity reaction mediated by CD4+ T cells specific for parasite egg antigens (Ags). In an attempt to control T-cell responses leading to excessive harmful inflammation and granuloma formation, especially in the liver, BALB/c mice were intranasally (i.n.) treated with soluble Schistosoma mansoni egg Ags (SEA) conjugated to cholera toxin B subunit (CTB), a mucosa-binding protein with demonstrated capacity to suppress inflammatory T-cell functions after mucosal administration. Treatment with CTB-SEA significantly conjugate a reduced liver granuloma formation in infected mice associated with decreased SEA specific Th1- and Th2-type immune responses by liver leukocytes. Importantly, treatment with CTB-SEA conjugate also significantly reduced the mortality in chronically infected mice. In S. mansoni-infected large-granuloma forming CBA mice, i.n. treatment with purified Sm-p40, the major egg antigen, conjugated to CTB likewise significantly inhibited hepatic egg granuloma formation. A reduction of SEA-driven lymphoproliferation and of interferon (IFN)-gamma, interleukin (IL)-4 and IL-5 production, together with an increase in transforming growth factor (TGF)-beta1 production, were observed in splenic cells from CTB-Sm-p40-treated SEA-sensitized mice, as well as in liver leukocytes from CTB-Sm-p40-treated schistosome-infected mice. These results indicate that mucosal administration of SEA or purified Sm-p40 antigen in conjunction with CTB is highly effective in curtailing immunopathologic manifestations of schistosomiasis in vivo in infected hosts.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Cholera Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Conjugate,
http://linkedlifedata.com/resource/pubmed/chemical/p40 egg antigen, Schistosoma
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0300-9475
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
54
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
440-7
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11696194-Administration, Intranasal,
pubmed-meshheading:11696194-Animals,
pubmed-meshheading:11696194-Antigens, Helminth,
pubmed-meshheading:11696194-Cholera Toxin,
pubmed-meshheading:11696194-Female,
pubmed-meshheading:11696194-Granuloma,
pubmed-meshheading:11696194-Helminth Proteins,
pubmed-meshheading:11696194-Immunity, Mucosal,
pubmed-meshheading:11696194-Liver,
pubmed-meshheading:11696194-Liver Diseases,
pubmed-meshheading:11696194-Mice,
pubmed-meshheading:11696194-Mice, Inbred BALB C,
pubmed-meshheading:11696194-Mice, Inbred CBA,
pubmed-meshheading:11696194-Ovum,
pubmed-meshheading:11696194-Schistosoma mansoni,
pubmed-meshheading:11696194-Schistosomiasis mansoni,
pubmed-meshheading:11696194-Th1 Cells,
pubmed-meshheading:11696194-Th2 Cells,
pubmed-meshheading:11696194-Vaccines, Conjugate
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| pubmed:year |
2001
|
| pubmed:articleTitle |
Nasal administration of Schistosoma mansoni egg antigen-cholera B subunit conjugate suppresses hepatic granuloma formation and reduces mortality in S. mansoni-infected mice.
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| pubmed:affiliation |
Department of Medical Microbiology and Immunology, University of Göteborg, Guldhedsgatan 10 A, SE-413 46 Göteborg, Sweden. jia-bin.sun@microbio.gu.se
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|