Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2001-11-6
pubmed:abstractText
Reduction of mechanical stress on bone inhibits osteoblast-mediated bone formation and accelerates osteoclast-mediated bone resorption, and leads to what has been called disuse osteoporosis. Prolonged therapeutic bed rest, immobilization due to motor paralysis from injury of the central nervous system or peripheral nerves, application of cast to treat fractures, a common causes of disuse osteoporosis. Imaging diagnosis shows coarse trabecular pattern and thinning of cortical bones. Bone metabolism markers have been used to evaluate bone metabolism. From the viewpoint of bone metabolism, antiresorptive agents should be administered to inhibit bone resorption. Rehabilitation, including bed positioning, therapeutic exercise and electrical stimulation, should be prescribed to subject the atrophied bone to an appropriate level of mechanical stress. In spite of these aggressive and continuous treatments, most cases of disuse osteoporosis require a long time for bone to recover its bone mineral density and strength. Hence, we have to keep in mind that there are no treatments better than prophylaxis of disuse osteoporosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1343-1420
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-56
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11694954-Autoimmune Diseases, pubmed-meshheading:11694954-Bed Rest, pubmed-meshheading:11694954-Biological Markers, pubmed-meshheading:11694954-Bone Resorption, pubmed-meshheading:11694954-Diagnostic Imaging, pubmed-meshheading:11694954-Diphosphonates, pubmed-meshheading:11694954-Electric Stimulation Therapy, pubmed-meshheading:11694954-Fractures, Bone, pubmed-meshheading:11694954-Humans, pubmed-meshheading:11694954-Immobilization, pubmed-meshheading:11694954-Osteoarthritis, pubmed-meshheading:11694954-Osteoblasts, pubmed-meshheading:11694954-Osteoclasts, pubmed-meshheading:11694954-Osteoporosis, pubmed-meshheading:11694954-Paralysis, pubmed-meshheading:11694954-Physical Therapy Modalities, pubmed-meshheading:11694954-Signal Transduction, pubmed-meshheading:11694954-Spinal Cord Injuries, pubmed-meshheading:11694954-Stress, Mechanical, pubmed-meshheading:11694954-Stroke, pubmed-meshheading:11694954-Weight-Bearing
pubmed:year
2001
pubmed:articleTitle
Disuse osteoporosis.
pubmed:affiliation
Department of Orthopedic Surgery, University of Tokushima School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan.
pubmed:publicationType
Journal Article, Review