Linked Life Data

11694453

Source:http://linkedlifedata.com/resource/pubmed/id/11694453

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-11-5
pubmed:abstractText
Interleukin (IL)-13, a cytokine released by T lymphocytes during immediate hypersensitivity responses, is a central mediator of asthma. Because IL-13 induces phenotypic features of asthma in mice deficient in T and B lymphocytes, it is likely that this cytokine contributes to the development of asthma by acting directly on resident airway cells. To analyze the global effects of IL-13 on gene expression in airway cells that could contribute to the phenotypic features of asthma, we used Genechip HuGene FL arrays (Affymetrix, Santa Clara, CA) that contain probes for approximately 6,500 human genes. Despite activating a common signaling pathway, IL-13 induced dramatically different patterns of gene expression in primary cultures of airway epithelial cells, airway smooth muscle cells, and lung fibroblasts, with little overlap among cell types. The most prominent effects of IL-13 were on airway smooth muscle, but several genes induced in airway epithelial cells and fibroblasts are also candidates that may contribute to phenotypic features of asthma. These results suggest that the in vivo response to IL-13 in the airways likely results from a combination of distinct effects on each of several resident airway cell types.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1044-1549
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
474-85
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11694453-Cells, Cultured, pubmed-meshheading:11694453-Endopeptidases, pubmed-meshheading:11694453-Extracellular Matrix Proteins, pubmed-meshheading:11694453-Fibroblasts, pubmed-meshheading:11694453-Gene Expression Regulation, pubmed-meshheading:11694453-Humans, pubmed-meshheading:11694453-Interleukin-13, pubmed-meshheading:11694453-Ion Channels, pubmed-meshheading:11694453-Muscle, Smooth, pubmed-meshheading:11694453-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:11694453-Protease Inhibitors, pubmed-meshheading:11694453-Respiratory Mucosa, pubmed-meshheading:11694453-Respiratory System, pubmed-meshheading:11694453-STAT6 Transcription Factor, pubmed-meshheading:11694453-Signal Transduction, pubmed-meshheading:11694453-Trans-Activators, pubmed-meshheading:11694453-Transcription, Genetic
pubmed:year
2001
pubmed:articleTitle
Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types.
pubmed:affiliation
Lung Biology Center, Cardiovascular Research Institute, University of California-San Francisco, San Francisco, CA 94143, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't