|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1-3
|
|
pubmed:dateCreated |
2001-11-5
|
|
pubmed:abstractText |
This review focuses on the molecular aspects of osteogenesis and chondrogenesis as they relate to cellular and developmental levels. We discuss BMP (bone morphogenetic protein)-mediated signaling pathways for the patterning of skeletal elements and mechanisms for the induction of cartilage and bone formation. We emphasize BMP-mediated initiation of chondrogenesis and osteogenesis and consider BMP-dependent signaling cascades in mesenchymal progenitor cells during the development of the axial and appendicular skeleton and during growth plate and joint formation. In particular, we discuss BMP-signaling mediators of the Smad and TAK family and the modulation of these signals by cross-talk and integration with other signaling pathways.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Hedgehog Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/MAP kinase kinase kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ROR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Tyrosine Kinase-like...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1045-4403
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
23-45
|
|
pubmed:dateRevised |
2011-11-2
|
|
pubmed:meshHeading |
pubmed-meshheading:11693963-Alkaline Phosphatase,
pubmed-meshheading:11693963-Animals,
pubmed-meshheading:11693963-Bone Morphogenetic Protein Receptors,
pubmed-meshheading:11693963-Bone Morphogenetic Proteins,
pubmed-meshheading:11693963-Calcitriol,
pubmed-meshheading:11693963-Cartilage,
pubmed-meshheading:11693963-Cell Differentiation,
pubmed-meshheading:11693963-Chondrocytes,
pubmed-meshheading:11693963-Embryonic and Fetal Development,
pubmed-meshheading:11693963-Extremities,
pubmed-meshheading:11693963-Feedback,
pubmed-meshheading:11693963-Gene Expression Regulation, Developmental,
pubmed-meshheading:11693963-Growth Plate,
pubmed-meshheading:11693963-Hedgehog Proteins,
pubmed-meshheading:11693963-MAP Kinase Kinase Kinases,
pubmed-meshheading:11693963-MAP Kinase Signaling System,
pubmed-meshheading:11693963-Mesoderm,
pubmed-meshheading:11693963-Mice,
pubmed-meshheading:11693963-Mice, Inbred C3H,
pubmed-meshheading:11693963-Mice, Knockout,
pubmed-meshheading:11693963-Models, Biological,
pubmed-meshheading:11693963-Multigene Family,
pubmed-meshheading:11693963-Osteoblasts,
pubmed-meshheading:11693963-Osteogenesis,
pubmed-meshheading:11693963-Proto-Oncogene Proteins,
pubmed-meshheading:11693963-Receptor Tyrosine Kinase-like Orphan Receptors,
pubmed-meshheading:11693963-Receptors, Cell Surface,
pubmed-meshheading:11693963-Receptors, Growth Factor,
pubmed-meshheading:11693963-Signal Transduction,
pubmed-meshheading:11693963-Somites,
pubmed-meshheading:11693963-Stem Cells,
pubmed-meshheading:11693963-Trans-Activators,
pubmed-meshheading:11693963-Transcription Factors,
pubmed-meshheading:11693963-Wnt Proteins,
pubmed-meshheading:11693963-Zebrafish Proteins
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
BMP signaling pathways in cartilage and bone formation.
|
|
pubmed:affiliation |
Osteogenesis Group, Gesellschaft für Biotechnologische Forschung (GBF), Braunschweig, Germany.
|
|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|
