Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1975-8-18
|
| pubmed:abstractText |
An equilibrium model is described for relationships between the biological activity and the physicochemical properties of compounds in a congeneric series. An equation derived from the model is of the form, log C = log (a + 10-alpha) = b, where C is the total molar concentration of drug to produce a standard response, alpha ia a parameter of the form log K where K is an equilibrium constant, and a and b are coefficients. This equation provides a plausible fit to some nonlinear observations which have been studied.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
231-3
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1169321-Anti-Bacterial Agents,
pubmed-meshheading:1169321-Anti-Infective Agents,
pubmed-meshheading:1169321-Bacteria,
pubmed-meshheading:1169321-Kinetics,
pubmed-meshheading:1169321-Mitosporic Fungi,
pubmed-meshheading:1169321-Models, Chemical,
pubmed-meshheading:1169321-Osmolar Concentration,
pubmed-meshheading:1169321-Regression Analysis,
pubmed-meshheading:1169321-Structure-Activity Relationship
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
Relationships between the biological and physicochemical properties of series of compounds.
|
| pubmed:publicationType |
Journal Article
|