Linked Life Data

11692154

Source:http://linkedlifedata.com/resource/pubmed/id/11692154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-11-5
pubmed:abstractText
A higher prevalence of hypertension has been associated with the G-->A/GT (Gly40Ser) polymorphism of the glucagon receptor gene (GCGR) in two population studies. As the mutated receptor is less responsive to glucagon, it has been speculated that the increased susceptibility to hypertension is due to deprivation of the recognized natriuretic effect of the hormone. To test this hypothesis we determined the frequency of the polymorphic variant and evaluated the segmental renal sodium handling by the clearances of uric acid and of exogenous lithium in the Olivetti Heart Study participants (n=971). The polymorphic variant was present only in heterozygous form in 37 individuals (3.8%). After controlling for age and body mass index, the carriers of the variant were twice more likely to be hypertensive and almost three times more likely to be on antihypertensive treatment at the time of examination. Compared to participants carrying the wild type, those carrying the Gly40Ser allele had higher serum uric acid and lower fractional excretion of uric acid and exogenous lithium, independently of age, body mass, and current pharmacological treatment. We conclude that the Gly40Ser polymorphism of the GCGR gene is associated with higher risk of hypertension and with enhanced proximal tubular sodium reabsorption, a factor possibly contributing to hypertension in this group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0946-2716
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
574-80
pubmed:dateRevised
2011-7-8
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant.
pubmed:affiliation
Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Unit of Clinical Genetics and Pharmacology, Hypertension and Mineral Metabolism, via S. Pansini 5, 80131 Naples, Italy. strazzul@unina.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't