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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-11-5
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pubmed:abstractText |
A highly conserved signaling property of Nef proteins encoded by human or simian immunodeficiency virus is the binding and activation of a PAK kinase whose function is unclear. Here we show that Nef-mediated p21-activated kinase (PAK) activation involves phosphatidylinositol 3-kinase, which acts upstream of PAK and is bound and activated by Nef similar to the manner of Polyoma virus middle T antigen. The Nef-associated phosphatidylinositol-3-PAK complex phosphorylated the pro-apoptotic Bad protein without involving the protein kinase B-Akt kinase, which is generally believed to inactivate Bad by serine phosphorylation. Consequently, Nef, but not a Nef mutant incapable of activating PAK, blocked apoptosis in T cells induced by serum starvation or HIV replication. Nef anti-apoptotic effects are likely a crucial mechanism for viral replication in the host and thus in AIDS pathogenesis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BAD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bad protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, nef,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-Associated Death Protein,
http://linkedlifedata.com/resource/pubmed/chemical/nef Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/p21-Activated Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1217-24
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11689886-3T3 Cells,
pubmed-meshheading:11689886-Animals,
pubmed-meshheading:11689886-Apoptosis,
pubmed-meshheading:11689886-Carrier Proteins,
pubmed-meshheading:11689886-Cell Line,
pubmed-meshheading:11689886-Gene Products, nef,
pubmed-meshheading:11689886-Genes, nef,
pubmed-meshheading:11689886-HIV-1,
pubmed-meshheading:11689886-Humans,
pubmed-meshheading:11689886-Mice,
pubmed-meshheading:11689886-Mutation,
pubmed-meshheading:11689886-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:11689886-Phosphorylation,
pubmed-meshheading:11689886-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11689886-Proto-Oncogene Proteins,
pubmed-meshheading:11689886-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:11689886-Signal Transduction,
pubmed-meshheading:11689886-Transfection,
pubmed-meshheading:11689886-Virus Replication,
pubmed-meshheading:11689886-bcl-Associated Death Protein,
pubmed-meshheading:11689886-nef Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:11689886-p21-Activated Kinases
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pubmed:year |
2001
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pubmed:articleTitle |
HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals.
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pubmed:affiliation |
Department of Dermatology Erlangen, University of Erlangen/Nürnberg, Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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