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rdf:type |
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lifeskim:mentions |
umls-concept:C0006675,
umls-concept:C0008018,
umls-concept:C0027950,
umls-concept:C0030685,
umls-concept:C0033268,
umls-concept:C0056693,
umls-concept:C0178719,
umls-concept:C0391871,
umls-concept:C0449297,
umls-concept:C0521009,
umls-concept:C0521119,
umls-concept:C0680255,
umls-concept:C0851285,
umls-concept:C1283071,
umls-concept:C1413221,
umls-concept:C1514873,
umls-concept:C1515655,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C1963578
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pubmed:issue |
11
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pubmed:dateCreated |
2001-11-5
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pubmed:abstractText |
Cyclic ADP-ribose is believed to be an important calcium-mobilizing second messenger in invertebrate, mammalian and plant cells. CD38, the best-characterized mammalian ADP-ribosyl cyclase, is postulated to be an important source of cyclic ADP-ribose in vivo. Using CD38-deficient mice, we demonstrate that the loss of CD38 renders mice susceptible to bacterial infections due to an inability of CD38-deficient neutrophils to directionally migrate to the site of infection. Furthermore, we show that cyclic ADP-ribose can directly induce intracellular Ca++ release in neutrophils and is required for sustained extracellular Ca++ influx in neutrophils that have been stimulated by the bacterial chemoattractant, formyl-methionyl-leucyl-phenylalanine (fMLP). Finally, we demonstrate that neutrophil chemotaxis to fMLP is dependent on Ca++ mobilization mediated by cyclic ADP-ribose. Thus, CD38 controls neutrophil chemotaxis to bacterial chemoattractants through its production of cyclic ADP-ribose, and acts as a critical regulator of inflammation and innate immune responses.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate Ribose,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Cd38 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic ADP-Ribose,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-Formylmethionine...,
http://linkedlifedata.com/resource/pubmed/chemical/NAD,
http://linkedlifedata.com/resource/pubmed/chemical/NAD Nucleosidase,
http://linkedlifedata.com/resource/pubmed/chemical/Ryanodine,
http://linkedlifedata.com/resource/pubmed/chemical/nicotinamide-8-bromoadenine...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-8956
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pubmed:author |
pubmed-author:CockayneD ADA,
pubmed-author:GarvyBB,
pubmed-author:GoodrichSS,
pubmed-author:HarmsenAA,
pubmed-author:HowardMM,
pubmed-author:JacobsonE LEL,
pubmed-author:KusserKK,
pubmed-author:MonardSS,
pubmed-author:OppenheimerNN,
pubmed-author:PAPERR,
pubmed-author:Partida-SánchezSS,
pubmed-author:RandallT DTD
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1209-16
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:11689885-ADP-ribosyl Cyclase,
pubmed-meshheading:11689885-Adenosine Diphosphate Ribose,
pubmed-meshheading:11689885-Animals,
pubmed-meshheading:11689885-Antigens, CD,
pubmed-meshheading:11689885-Antigens, CD38,
pubmed-meshheading:11689885-Antigens, Differentiation,
pubmed-meshheading:11689885-Calcium Signaling,
pubmed-meshheading:11689885-Chemotaxis, Leukocyte,
pubmed-meshheading:11689885-Cyclic ADP-Ribose,
pubmed-meshheading:11689885-Lymphoid Tissue,
pubmed-meshheading:11689885-Membrane Glycoproteins,
pubmed-meshheading:11689885-Mice,
pubmed-meshheading:11689885-Mice, Inbred C57BL,
pubmed-meshheading:11689885-Mice, Knockout,
pubmed-meshheading:11689885-N-Formylmethionine Leucyl-Phenylalanine,
pubmed-meshheading:11689885-NAD,
pubmed-meshheading:11689885-NAD+ Nucleosidase,
pubmed-meshheading:11689885-Neutrophils,
pubmed-meshheading:11689885-Pneumococcal Infections,
pubmed-meshheading:11689885-Ryanodine,
pubmed-meshheading:11689885-Streptococcus pneumoniae
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pubmed:year |
2001
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pubmed:articleTitle |
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo.
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pubmed:affiliation |
Trudeau Institute, Saranac Lake, New York, USA.
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pubmed:publicationType |
Journal Article
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