Source:http://linkedlifedata.com/resource/pubmed/id/11689062
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23
|
| pubmed:dateCreated |
2001-11-5
|
| pubmed:abstractText |
A hypothetical pharmacophore of 5 alpha-reductase inhibitors was generated and served as a template in virtual screening. When the pharmacophore was used, eight isoflavone derivatives were characterized as novel potential nonsteroidal inhibitors of rat 5 alpha-reductase. This investigation has demonstrated a practical approach toward the development of lead compounds through a hypothetic pharmacophore via three-dimensional database searching.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
8
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3759-63
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:11689062-3-Oxo-5-alpha-Steroid 4-Dehydrogenase,
pubmed-meshheading:11689062-5-alpha Reductase Inhibitors,
pubmed-meshheading:11689062-Animals,
pubmed-meshheading:11689062-Binding Sites,
pubmed-meshheading:11689062-Databases, Factual,
pubmed-meshheading:11689062-Enzyme Inhibitors,
pubmed-meshheading:11689062-Isoflavones,
pubmed-meshheading:11689062-Microsomes, Liver,
pubmed-meshheading:11689062-Models, Molecular,
pubmed-meshheading:11689062-Rats,
pubmed-meshheading:11689062-Structure-Activity Relationship
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Novel lead generation through hypothetical pharmacophore three-dimensional database searching: discovery of isoflavonoids as nonsteroidal inhibitors of rat 5 alpha-reductase.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|