Linked Life Data

11688457

Source:http://linkedlifedata.com/resource/pubmed/id/11688457

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-11-1
pubmed:abstractText
We report on six boys with intratubular Sertoli cell proliferations (ISCPs), studied by routine histologic methods, electron microscopy, and immunohistochemistry of anti-müllerian hormone (AMH), inhibin alpha-subunit, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), proliferative cellular nuclear antigen, and p53, and carefully followed for extended periods with periodic clinical examinations, testicular ultrasonographies, and determinations of serum levels of AMH and inhibin B. Peutz-Jeghers syndrome was found in four of six patients, and gynecomastia occurred in five of six patients. One boy had isosexual pseudoprecocity. ISCPs were observed as multiple foci of seminiferous tubules with large and proliferated Sertoli cells replacing germ cells and limited by the basement membrane. Mitotic figures, atypia, and/or interstitial invasion were not observed. Bilateral ISCPs were the only pathologic finding in three patients (patient nos. 1-3) and were associated with a microscopic tumor that resembled a large-cell calcifying Sertoli cell tumor (LCCSCT) in a fourth patient (patient no. 4). In the two remaining patients (patient nos. 5 and 6) ISCPs and LCCSCT were found in both testes. Ultrastructural examination showed large Sertoli cells, with round nuclei, sparse organelles, and some glycogen. Inhibin alpha-subunit immunolocalization was positive in the five patients in whom it was determined (patient nos. 2-6), AMH was positive in those ISCPs associated with tumors (patient nos. 4-6) and negative in isolated ISCPs (patient nos. 2 and 3); 3beta-HSD and PCNA were variable, and p53 was negative in all ISCPs. Patient nos. 1-4 have been followed for 2-19 years. One of them is currently entering puberty, the other two have already completed puberty and have testes of normal size, and the remaining one is an adult with clinically normal testes and sperm production. None of these patients had evidence of tumor development during follow-up as shown by serial ultrasonographies and serum levels of AMH and inhibin B. Patient nos. 5 and 6 who had bilateral ISCPs and LCCSCT were orchidectomized and evolved for 2-10 years after surgery without tumor recurrence. The prognostic significance of ISCPs, particularly when they are the only pathologic finding in a testicular biopsy, is a matter of controversy. Based on the long normal evolution, we recommend a conservative approach to therapy. The bilateral and multicentric character of ISCPs and their association with Sertoli tumors and Peutz-Jeghers syndrome suggest that they represent either proliferative lesions with tumorigenic potential or the intraepithelial stage in the evolution of some testicular Sertoli cell tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0147-5185
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1237-44
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11688457-3-Hydroxysteroid Dehydrogenases, pubmed-meshheading:11688457-Adolescent, pubmed-meshheading:11688457-Anti-Mullerian Hormone, pubmed-meshheading:11688457-Cell Division, pubmed-meshheading:11688457-Child, pubmed-meshheading:11688457-Follow-Up Studies, pubmed-meshheading:11688457-Glycoproteins, pubmed-meshheading:11688457-Growth Inhibitors, pubmed-meshheading:11688457-Humans, pubmed-meshheading:11688457-Inhibins, pubmed-meshheading:11688457-Male, pubmed-meshheading:11688457-Peutz-Jeghers Syndrome, pubmed-meshheading:11688457-Precancerous Conditions, pubmed-meshheading:11688457-Proliferating Cell Nuclear Antigen, pubmed-meshheading:11688457-Sertoli Cell Tumor, pubmed-meshheading:11688457-Sertoli Cells, pubmed-meshheading:11688457-Testicular Hormones, pubmed-meshheading:11688457-Testicular Neoplasms, pubmed-meshheading:11688457-Tumor Suppressor Protein p53
pubmed:year
2001
pubmed:articleTitle
Sertoli cell proliferations of the infantile testis: an intratubular form of Sertoli cell tumor?
pubmed:affiliation
Endocrinology Division, Children's Hospital Ricardo Gutiérrez, CONICET, Buenos Aires, Argentina. hchemes@cedie.guti.gov.ar
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't