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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-11-5
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pubmed:abstractText |
Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are believed to play a significant role in the pathogenesis of inflammatory bowel disease (IBD). Interleukin-1 and TNF-alpha possess overlapping and synergetic activities inducing the production in cascade of other cytokines, adhesion molecules, arachidonic acid metabolites, as well as activating immune and non-immune cells. FR167653 (C24H18FN5O2-H2SO4-H2O) is a newly synthesized organic compound with a potent inhibitory effect on IL-1beta and TNF-alpha production. We hypothesized that the suppression of IL-1 and TNF-alpha induced by FR167653 could effectively attenuate experimentally induced colonic damage.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0815-9319
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1105-11
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11686836-Acetic Acid,
pubmed-meshheading:11686836-Acute Disease,
pubmed-meshheading:11686836-Analysis of Variance,
pubmed-meshheading:11686836-Animals,
pubmed-meshheading:11686836-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11686836-Colitis,
pubmed-meshheading:11686836-Disease Models, Animal,
pubmed-meshheading:11686836-Interleukin-1,
pubmed-meshheading:11686836-Male,
pubmed-meshheading:11686836-Molecular Structure,
pubmed-meshheading:11686836-Pyrazoles,
pubmed-meshheading:11686836-Pyridines,
pubmed-meshheading:11686836-Rats,
pubmed-meshheading:11686836-Rats, Sprague-Dawley,
pubmed-meshheading:11686836-Tumor Necrosis Factor-alpha
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pubmed:year |
2001
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pubmed:articleTitle |
FR167653, a potent suppressant of interleukin-1 and tumor necrosis factor-alpha production, ameliorates colonic lesions in experimentally induced acute colitis.
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pubmed:affiliation |
First Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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