Linked Life Data

11684885

Source:http://linkedlifedata.com/resource/pubmed/id/11684885

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-10-30
pubmed:abstractText
Circulating insulin-like growth factor I (IGF-I) levels are stable throughout the day and correlate with pulsatile endogenous growth hormone (GH) secretion. A single measurement of IGF-I may, therefore, provide information on the GH secretory status of an individual. The clinical use of IGF-I determination in the evaluation of short stature in children suspected of GH deficiency will be discussed. Previous methodological problems have now mostly been overcome, and IGF-I can be determined in serum from healthy children, although concentrations exhibit large inter-individual variations relating to age, gender and pubertal maturation. These variations must be taken into account before IGF-I can be evaluated in a clinical situation, and before it can be stated whether a certain value is too low for a given age. The diagnostic sensitivities of IGF-I reported in relation to the outcome of GH provocative testing are variable (47-100%). This variability probably results from the use of different IGF-I assays, IGF-I reference ranges, and different GH testing procedures. When proper IGF-I assays and reference ranges are used, however, IGF-I determination results in valid diagnostic information regarding children exhibiting short stature. Thus, an IGF-I value should always be evaluated together with auxological information and GH testing results before a decision is taken on whether or not to start GH therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-0163
pubmed:author
pubmed:copyrightInfo
Copyright 2001 S. Karger AG, Basel
pubmed:issnType
Print
pubmed:volume
55 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
94-9
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Determination of insulin-like growth factor I in children: normal values and clinical use.
pubmed:affiliation
Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark. ajuul@dadlnet.dk
pubmed:publicationType
Journal Article, Review