Linked Life Data

11684343

Source:http://linkedlifedata.com/resource/pubmed/id/11684343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-10-30
pubmed:abstractText
The actions of melatonin on high-voltage activated calcium channels (HVACC) and intracellular free Ca(2+) concentration in cultured dorsal root ganglion (DRG) neurones from neonatal rats were investigated using the whole-cell patch clamp and the fura-2 fluorescence ratio Ca(2+)-imaging techniques. HVACC were pharmacologically and biophysically isolated and the effects of melatonin were investigated. Extracellular application of melatonin inhibited HVACC in a dose dependent manner. In calcium imaging experiments, application of extracellular recording medium containing 30 mM KCl evoked increases in intracellular free Ca(2+) that were dependent upon external Ca(2+) ions. This increase was prevented by both low (10 microM) and high dose (100 microM) of melatonin pre-treatment. The results of this study indicate that the pineal hormone melatonin has inhibitory actions on voltage dependent calcium entry in cultured rat DRG neurones.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
313
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Melatonin inhibits high voltage activated calcium currents in cultured rat dorsal root ganglion neurones.
pubmed:affiliation
Firat University, Faculty of Medicine, Department of Pharmacology, TR-23200 Elazig, Turkey. a.ayar@mailexcite.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't