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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0065752,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0212320,
umls-concept:C0342649,
umls-concept:C0449774,
umls-concept:C0679688,
umls-concept:C1563937,
umls-concept:C1979844,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2001-10-30
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pubmed:abstractText |
Increasing evidence suggests that vascular calcification is a regulated process. We studied the vascular expression pattern of a key factor in mineralization and a counteracting, protective factor. Based on the phenotype of null mice, Core binding factor alpha-1 (Cbfa-1) plays a pivotal role in bone formation, whereas Matrix Gla Protein (MGP) is a potent inhibitor of vascular calcification.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11684076-Arteriosclerosis,
pubmed-meshheading:11684076-Calcinosis,
pubmed-meshheading:11684076-Calcium-Binding Proteins,
pubmed-meshheading:11684076-Case-Control Studies,
pubmed-meshheading:11684076-Cells, Cultured,
pubmed-meshheading:11684076-Core Binding Factors,
pubmed-meshheading:11684076-Endothelium, Vascular,
pubmed-meshheading:11684076-Extracellular Matrix Proteins,
pubmed-meshheading:11684076-Humans,
pubmed-meshheading:11684076-Immunohistochemistry,
pubmed-meshheading:11684076-In Situ Hybridization,
pubmed-meshheading:11684076-Macrophages,
pubmed-meshheading:11684076-Muscle, Smooth, Vascular,
pubmed-meshheading:11684076-Neoplasm Proteins,
pubmed-meshheading:11684076-RNA, Messenger,
pubmed-meshheading:11684076-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11684076-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Vascular calcification: expression patterns of the osteoblast-specific gene core binding factor alpha-1 and the protective factor matrix gla protein in human atherogenesis.
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pubmed:affiliation |
Department of Biochemistry, Academic Medical Center K1-163, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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