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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-10-30
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pubmed:abstractText |
The Ca(2+) independent transient outward K(+) current (I(to1)) in the heart is responsible for the initial phase of repolarization. The hKv4.3 K(+) channel alpha-subunit contributes to the I(to1) current in many regions of the human heart. Consistently, downregulation of hKv4.3 transcripts in heart failure and atrial fibrillation is linked to reduction in I(to1) conductance. The recently cloned KChIP family of calcium sensors has been shown to modulate A-type potassium channels of the Kv4 K(+) channel subfamily.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/KCND3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KCNIP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Kv Channel-Interacting Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Shal Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Exchanging ATPase
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
255-64
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11684073-Alternative Splicing,
pubmed-meshheading:11684073-Animals,
pubmed-meshheading:11684073-Blotting, Northern,
pubmed-meshheading:11684073-Calcium-Binding Proteins,
pubmed-meshheading:11684073-Chromosome Mapping,
pubmed-meshheading:11684073-Chromosomes, Human, Pair 10,
pubmed-meshheading:11684073-Cloning, Molecular,
pubmed-meshheading:11684073-Female,
pubmed-meshheading:11684073-Gene Expression,
pubmed-meshheading:11684073-Gene Transfer Techniques,
pubmed-meshheading:11684073-Humans,
pubmed-meshheading:11684073-Introns,
pubmed-meshheading:11684073-Kv Channel-Interacting Proteins,
pubmed-meshheading:11684073-Myocardium,
pubmed-meshheading:11684073-Oocytes,
pubmed-meshheading:11684073-Patch-Clamp Techniques,
pubmed-meshheading:11684073-Polymerase Chain Reaction,
pubmed-meshheading:11684073-Potassium Channels,
pubmed-meshheading:11684073-Potassium Channels, Voltage-Gated,
pubmed-meshheading:11684073-Protein Isoforms,
pubmed-meshheading:11684073-Sequence Analysis, DNA,
pubmed-meshheading:11684073-Shal Potassium Channels,
pubmed-meshheading:11684073-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:11684073-Xenopus laevis
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pubmed:year |
2001
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pubmed:articleTitle |
hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant.
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pubmed:affiliation |
Aventis Pharma Deutschland GmbH, DG Cardiovascular Diseases, D-65926, Frankfurt am Main, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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