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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0012860,
umls-concept:C0032136,
umls-concept:C0034538,
umls-concept:C0043240,
umls-concept:C0205460,
umls-concept:C0220806,
umls-concept:C0302912,
umls-concept:C0374711,
umls-concept:C0376446,
umls-concept:C0439851,
umls-concept:C0443286,
umls-concept:C1280500,
umls-concept:C1552596,
umls-concept:C1705181,
umls-concept:C1947931
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pubmed:issue |
11
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pubmed:dateCreated |
2001-10-30
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pubmed:abstractText |
It has been previously argued that the use of the one-electron oxidants (SCN)2(*-) and Br2(*-) with plasmid DNA leads to the formation of DNA guanyl radicals. These guanyl radical species are intermediates in the DNA damage produced by processes such as photo-ionization and ionizing irradiation. The present paper evaluates the use of thallium(II) ions (Tl(II)OH(+)) as the one-electron oxidant, and also determines rate constants for the reduction (repair) of guanyl radicals in plasmid DNA by a variety of reducing agents including the biologically important compounds ascorbate and glutathione.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Single-Stranded,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Formamidopyrimidine Glycosylase,
http://linkedlifedata.com/resource/pubmed/chemical/Ferrocyanides,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/N-Glycosyl Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Perchloric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Thallium,
http://linkedlifedata.com/resource/pubmed/chemical/Thiocyanates,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/hexacyanoferrate II,
http://linkedlifedata.com/resource/pubmed/chemical/sodium perchlorate,
http://linkedlifedata.com/resource/pubmed/chemical/thiocyanate
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0955-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1095-108
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11683980-DNA,
pubmed-meshheading:11683980-DNA, Single-Stranded,
pubmed-meshheading:11683980-DNA Damage,
pubmed-meshheading:11683980-DNA Repair,
pubmed-meshheading:11683980-DNA-Formamidopyrimidine Glycosylase,
pubmed-meshheading:11683980-Ferrocyanides,
pubmed-meshheading:11683980-Free Radical Scavengers,
pubmed-meshheading:11683980-Free Radicals,
pubmed-meshheading:11683980-Kinetics,
pubmed-meshheading:11683980-N-Glycosyl Hydrolases,
pubmed-meshheading:11683980-Oxidation-Reduction,
pubmed-meshheading:11683980-Perchloric Acid,
pubmed-meshheading:11683980-Plasmids,
pubmed-meshheading:11683980-Radiation, Ionizing,
pubmed-meshheading:11683980-Sodium Compounds,
pubmed-meshheading:11683980-Thallium,
pubmed-meshheading:11683980-Thiocyanates,
pubmed-meshheading:11683980-Tyrosine
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pubmed:year |
2001
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pubmed:articleTitle |
Reaction of guanyl radicals in plasmid DNA with biological reductants: chemical repair of DNA damage produced by the direct effect of ionizing radiation.
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pubmed:affiliation |
Department of Radiology, University of California at San Diego, La Jolla, CA 92093-0610, USA. jmilligan@ucsd.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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