Linked Life Data

1168292

Source:http://linkedlifedata.com/resource/pubmed/id/1168292

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1975-7-2
pubmed:abstractText
Ultrastructural studies were made of the central nervous system of three goats during the early stages of viral leukoencephalomyelitis of goats and of one goat 3 years after onset of the disease. In both early and late lesions, the following features were recognized: loss of myelin from normal axons, separation of the myelin sheath from the axon by cell processes, pronounced astrocytosis with numerous cell processes packed with heavy fibrils, paucity of oligodendrocytes, normal capillaries, and normal cellular elements in the adjacent gray matter. Early lesions also had many cells of the lymphoid series infiltrating perivascular spaces, within lesions, and, particularly, along axons undergoing demyelination. Although viral particles were extensively sought, only one suspect structure, with a tubular nucleocapsid-like configuration, was seen. Individual tubules of this particle measured 22 nm. in diameter. The ultrastructural features of demyelination in viral leukoencephalomyelitis of goats were compared with those described for demyelination that occurs in multiple sclerosis, experimental allergic encephalomyelitis, canine distemper encephalomyelitis, and that produced by diphtheria toxin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
359-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Ultrastructural features of viral leukoencephalomyelitis of goats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.