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pubmed-article:11682226rdf:typepubmed:Citationlld:pubmed
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pubmed-article:11682226pubmed:dateCreated2001-10-29lld:pubmed
pubmed-article:11682226pubmed:abstractTextStudies on the capabilities of flow injection analysis (FIA) combined with on-line characterisation of model compounds via a combination of diode array UV, 1H-NMR, FT-IR spectroscopy and mass spectrometry are described. Using this combination of spectrometers enabled the on-flow collection of UV, 1H-NMR, IR and MS for a range of model compounds. Samples were introduced into the system as solutions in deuterium oxide in concentrations ranging from 1.4 to 8.4 mg ml(-1). A sample volume of 100 microl was used for FIA at a flow rate of 1 ml min(-1). From these studies a practical working quantity of ca. 140 microg/sample of analyte was determined which provided characteristic spectra.lld:pubmed
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pubmed-article:11682226pubmed:pagination191-200lld:pubmed
pubmed-article:11682226pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11682226pubmed:year2002lld:pubmed
pubmed-article:11682226pubmed:articleTitleFlow injection analysis with multiple on-line spectroscopic analysis (UV, IR, 1H-NMR and MS).lld:pubmed
pubmed-article:11682226pubmed:affiliationAstraZeneca Pharmaceuticals, Drug Metabolism & Pharmacokinetics Department, Mereside, Alderley Park, Macclesfield, SK10 4TG, Cheshire, UK.lld:pubmed
pubmed-article:11682226pubmed:publicationTypeJournal Articlelld:pubmed