Linked Life Data

1168220

Source:http://linkedlifedata.com/resource/pubmed/id/1168220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1975-6-18
pubmed:abstractText
The kinetics of immunoglobulin-synthesizing cells (IFC) and antibody-forming cells (AFC) are compared in the popliteal nodes of mice challenged, in the hind footpads, with horseradish peroxidase (PO) in Freund's complete adjuvant. A rise in the number of IFC without antibody function precedes the appearance of AFC. IFC reach peak numbers 7 days before AFC. Control experiments show that the majority of IFC without antibody function are responding to PO and not to adjuvant. Kinetic and radioautographic data suggest that IFC arise by division and differentiation; however, the doubling time of AFC is too rapid to be accounted for by cell division alone. Double staining techniques revealed the presence of immunoglobulin and antibody in different compartments of the same cell in 5 to 15% of the AFC. It is postulated that some AFC are recruited, possibly from cells already synthesizing immunoglobulin determinants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
626-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Synthesis of antibody and immunoglobulins without detectable antibody function in cells responding to horseradish peroxidase.
pubmed:publicationType
Journal Article