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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-10-29
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pubmed:abstractText |
PURPOSE: Allopurinol has beneficial effects in the systemic treatment of lens-induced uveitis and experimental autoimmune uveitis (EAU). This is believed to be due to a reduction of oxidative tissue damage through its dose-dependent free radical scavenging ability, and to an immunomodulating effect. The purpose of this study was to demonstrate the immunological effects on the IgG-antibody repertoire in EAU after topical and systemic allopurinol and steroids. METHODS: We assigned 43 male Lewis rats to 6 different groups: healthy rats (BASE, n=3)
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1120-6721
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
252-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11681504-Adjuvants, Immunologic,
pubmed-meshheading:11681504-Administration, Topical,
pubmed-meshheading:11681504-Allopurinol,
pubmed-meshheading:11681504-Animals,
pubmed-meshheading:11681504-Autoantibodies,
pubmed-meshheading:11681504-Autoantigens,
pubmed-meshheading:11681504-Autoimmune Diseases,
pubmed-meshheading:11681504-Blotting, Western,
pubmed-meshheading:11681504-Disease Models, Animal,
pubmed-meshheading:11681504-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:11681504-Free Radical Scavengers,
pubmed-meshheading:11681504-Glucocorticoids,
pubmed-meshheading:11681504-Immunoglobulin G,
pubmed-meshheading:11681504-Injections, Intravenous,
pubmed-meshheading:11681504-Male,
pubmed-meshheading:11681504-Rats,
pubmed-meshheading:11681504-Rats, Inbred Lew,
pubmed-meshheading:11681504-Uveitis
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pubmed:articleTitle |
Allopurinol has immunomodulating activity following topical and systemic application in experimental autoimmune uveitis.
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pubmed:affiliation |
Department of Ophthalmology, University of Mainz, Germany. Fgrus@CSI.COM
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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