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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-10-26
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pubmed:abstractText |
The mammalian HBP2 gene has been isolated by functional complementation of cells unable to undergo DNA replication in fission yeast. HBP2 is a protein with a high mobility group (HMG) domain that belongs to the Sox (Sry-related HMG box) family of transcription factors. As in other members of the family, the HMG box in HBP2 is a DNA-binding domain that is essential for its function in Schizosaccharomyces pombe. Expression of HBP2 in fission yeast activates CdclO-dependent transcription at G1/S and allows growth of cdc10-129, resldelta and rep2delta mutant cells at the restrictive temperature. The mammalian HBP2 activates transcription at G1/S in the fission yeast Sch. pombe.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDC10 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GTP Phosphohydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/MBP1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Localization Signals,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Schizosaccharomyces pombe Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sept7 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Septins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/cdc10 protein, S pombe
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0172-8083
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
110-8
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11680820-Amino Acid Sequence,
pubmed-meshheading:11680820-Animals,
pubmed-meshheading:11680820-Cell Cycle Proteins,
pubmed-meshheading:11680820-Cloning, Molecular,
pubmed-meshheading:11680820-G1 Phase,
pubmed-meshheading:11680820-GTP Phosphohydrolases,
pubmed-meshheading:11680820-Genetic Complementation Test,
pubmed-meshheading:11680820-HMG-Box Domains,
pubmed-meshheading:11680820-Humans,
pubmed-meshheading:11680820-Mammals,
pubmed-meshheading:11680820-Membrane Proteins,
pubmed-meshheading:11680820-Mice,
pubmed-meshheading:11680820-Molecular Sequence Data,
pubmed-meshheading:11680820-Mutation,
pubmed-meshheading:11680820-Nuclear Localization Signals,
pubmed-meshheading:11680820-S Phase,
pubmed-meshheading:11680820-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:11680820-Schizosaccharomyces,
pubmed-meshheading:11680820-Schizosaccharomyces pombe Proteins,
pubmed-meshheading:11680820-Septins,
pubmed-meshheading:11680820-Sequence Homology, Amino Acid,
pubmed-meshheading:11680820-Trans-Activators,
pubmed-meshheading:11680820-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex.
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pubmed:affiliation |
Instituto de Microbiologia Bioquimica, Departamento de Microbiologia y Genética, CSIC/Universidad de Salamanca, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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