Source:http://linkedlifedata.com/resource/pubmed/id/11678663
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
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| pubmed:dateCreated |
2001-10-26
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| pubmed:abstractText |
Chondropsin D (2), a new 37-membered-ring macrolide lactam, was isolated as a minor constituent of an aqueous extract of the marine sponge Chondropsis sp. This sponge sample had previously been the source of chondropsins A (1) and B, two novel polyketide-derived macrolides with potent cytotoxic activity. The structure of 2 was initially deduced from analysis of spectral data. This assignment was supported by the observation that chondropsin A (1), which contains a 35-membered macrocyclic ring, could be converted to chondropsin D (2) by a base-catalyzed intramolecular transesterification reaction. Rearrangement of the methylated derivative of chondropsin A (3) to the corresponding methylated analogue of chondropsin D (4) confirmed the structure of 2.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0163-3864
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
64
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1341-4
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11678663-Animals,
pubmed-meshheading:11678663-Antineoplastic Agents,
pubmed-meshheading:11678663-Australia,
pubmed-meshheading:11678663-Chromatography, High Pressure Liquid,
pubmed-meshheading:11678663-Drug Screening Assays, Antitumor,
pubmed-meshheading:11678663-Humans,
pubmed-meshheading:11678663-Lactams,
pubmed-meshheading:11678663-Leukemia, Lymphoid,
pubmed-meshheading:11678663-Macrolides,
pubmed-meshheading:11678663-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11678663-Mass Spectrometry,
pubmed-meshheading:11678663-Melanoma,
pubmed-meshheading:11678663-Molecular Structure,
pubmed-meshheading:11678663-Porifera,
pubmed-meshheading:11678663-Spectrophotometry, Infrared,
pubmed-meshheading:11678663-Spectrophotometry, Ultraviolet,
pubmed-meshheading:11678663-Tumor Cells, Cultured
|
| pubmed:year |
2001
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| pubmed:articleTitle |
Chondropsin D, a new 37-membered-ring macrolide lactam from the marine sponge Chondropsis species.
|
| pubmed:affiliation |
Molecular Targets Drug Discovery Program, Center for Cancer Research, National Cancer Institute-Frederick, Building 1052, Room 121, Frederick, MD 21702-1201, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|