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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-10-25
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pubmed:abstractText |
The multidrug resistance protein (MRP) isoforms MRP2 (ABCC2) and MRP3 (ABCC3) play a decisive role in the hepatic secretion of endogenous and xenobiotic conjugates and are differentially expressed in hepatocytes and cholangiocytes. The epithelium of the gallbladder considerably modifies the composition of primary hepatic bile by absorption and secretion; however, the underlying transport mechanisms were largely unknown. Localization of MRP2 and MRP3 may provide an explanation of how the products of phase II conjugation are effluxed from gallbladder epithelia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1203-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11677213-Aged,
pubmed-meshheading:11677213-Female,
pubmed-meshheading:11677213-Gallbladder,
pubmed-meshheading:11677213-Humans,
pubmed-meshheading:11677213-Male,
pubmed-meshheading:11677213-Membrane Transport Proteins,
pubmed-meshheading:11677213-Microscopy, Fluorescence,
pubmed-meshheading:11677213-Middle Aged,
pubmed-meshheading:11677213-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:11677213-RNA, Messenger,
pubmed-meshheading:11677213-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2001
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pubmed:articleTitle |
Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia.
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pubmed:affiliation |
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany. Daniel_Rost@med.uni-heidelberg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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