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rdf:type |
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lifeskim:mentions |
umls-concept:C0020792,
umls-concept:C0166417,
umls-concept:C0205549,
umls-concept:C0220781,
umls-concept:C0243192,
umls-concept:C0439097,
umls-concept:C1547348,
umls-concept:C1554184,
umls-concept:C1705241,
umls-concept:C1883254,
umls-concept:C2348042
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|
pubmed:issue |
22
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pubmed:dateCreated |
2001-10-25
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|
pubmed:abstractText |
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound 23 showed good plasma exposure in rats and demonstrated antihyperglycemic and antihyperlipidemic efficacy in diabetic fatty Zucker rats.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
11
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2959-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11677135-Animals,
pubmed-meshheading:11677135-DNA-Binding Proteins,
pubmed-meshheading:11677135-Diabetes Mellitus,
pubmed-meshheading:11677135-Enzyme Activators,
pubmed-meshheading:11677135-Hyperglycemia,
pubmed-meshheading:11677135-Hyperlipidemias,
pubmed-meshheading:11677135-Ligands,
pubmed-meshheading:11677135-Rats,
pubmed-meshheading:11677135-Rats, Zucker,
pubmed-meshheading:11677135-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:11677135-Transcription Factors
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.
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|
pubmed:affiliation |
Nuclear Receptor Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709, USA. kevin_liu@stromix.com
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pubmed:publicationType |
Journal Article
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