Linked Life Data

11676852

Source:http://linkedlifedata.com/resource/pubmed/id/11676852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-10-25
pubmed:abstractText
The modifying effects of three kinds of fat (corn oil, beef tallow or perilla oil, each at 20% in the diet) on F344 rat prostate carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl (DMAB) were investigated. Non-invasive carcinomas of the ventral prostate were induced by DMAB alone and invasive carcinomas of the other prostate lobes and seminal vesicles by DMAB and testosterone propionate (TP). Eight groups of F344 rats were initiated with 50 mg / kg body weight of DMAB at 2-week intervals for the first 20 weeks, four also receiving TP, extended until week 60. The animals received basal chow powder diet or one of three high fat diets throughout the experiment (60 weeks). One further group served as a non-carcinogen-treated control maintained on basal chow powder diet. Beef tallow significantly increased the development of ventral prostate carcinomas with DMAB alone (from 15 to 45%, P < 0.05), while perilla oil reduced the incidence of prostatic intraepithelial neoplasia (PIN) in the ventral lobe of rats given DMA + TP (from 70 to 10%, P < 0.01), but not in those given DMAB alone. No other effects of high fats were observed regarding PIN or invasive cancers of the dorsolateral and anterior prostate or seminal vesicles. A satellite experiment demonstrated that all high fat diets for 4 weeks increased the 5-bromo-2-deoxyuridine (BrdU) labeling index of prostate epithelial cells, suggesting that a high fat intake, irrespective of the fatty acid composition, may accelerate cell kinetics in the prostate. Of the three high fat diets, beef tallow was also found to increase intestinal carcinogenesis. Thus, the present data revealed carcinogenesis in the prostate and intestine to be promoted by beef tallow.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0910-5050
pubmed:author
pubmed:issnType
Print
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1026-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11676852-Aminobiphenyl Compounds, pubmed-meshheading:11676852-Animals, pubmed-meshheading:11676852-Body Weight, pubmed-meshheading:11676852-Carcinogens, pubmed-meshheading:11676852-Cattle, pubmed-meshheading:11676852-Corn Oil, pubmed-meshheading:11676852-Dietary Fats, pubmed-meshheading:11676852-Fats, pubmed-meshheading:11676852-Incidence, pubmed-meshheading:11676852-Intestinal Neoplasms, pubmed-meshheading:11676852-Male, pubmed-meshheading:11676852-Meat, pubmed-meshheading:11676852-Organ Size, pubmed-meshheading:11676852-Plant Oils, pubmed-meshheading:11676852-Prostate, pubmed-meshheading:11676852-Prostatic Neoplasms, pubmed-meshheading:11676852-Rats, pubmed-meshheading:11676852-Rats, Inbred F344, pubmed-meshheading:11676852-Seminal Vesicles, pubmed-meshheading:11676852-alpha-Linolenic Acid
pubmed:year
2001
pubmed:articleTitle
Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl.
pubmed:affiliation
First Department of Pathology, Nagoya City University Medical School, Mizuho-ku, Nagoya 467-8601.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't