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rdf:type |
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lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0026844,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0296735,
umls-concept:C0392747,
umls-concept:C0449432,
umls-concept:C1135918,
umls-concept:C1179435,
umls-concept:C1419255,
umls-concept:C1424497,
umls-concept:C1515670,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248
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pubmed:issue |
3
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pubmed:dateCreated |
2001-10-25
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pubmed:abstractText |
Adrenomedullin is known to inhibit cell proliferation in cultured rat vascular smooth muscle cells, through a cAMP-dependent process. The calcitonin receptor-like receptor could function as an adrenomedullin receptor when co-expressed with receptor activity-modifying protein 2. To determine whether vascular adrenomedullin receptor components, the calcitonin receptor-like receptor and the receptor activity-modifying protein 2, phenotypically change during in vitro culture conditions, we examined the expression of adrenomedullin receptor components, adrenomedullin-induced cAMP production, and the inhibition of cell proliferation in culture rat vascular smooth muscle cells during serial passages. The results demonstrated that the receptor activity-modifying protein 2 and calcitonin receptor-like receptor mRNAs increased in a passage-dependent manner in rat vascular smooth muscle cells. Furthermore, the responses of both the elevation of cAMP and the inhibition of cell proliferation became larger in vascular smooth muscle cells with an increasing number of passages. The results suggest that the increase in functional AM receptor during phenotypic change may in part contribute to the development of vascular lesions, such as in atherosclerosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenomedullin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Receptor-Like Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Calcrl protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Ramp2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activity-Modifying...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activity-Modifying Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenomedullin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Calcitonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
515-20
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11676473-Adrenomedullin,
pubmed-meshheading:11676473-Animals,
pubmed-meshheading:11676473-Aorta,
pubmed-meshheading:11676473-Calcitonin Gene-Related Peptide,
pubmed-meshheading:11676473-Calcitonin Receptor-Like Protein,
pubmed-meshheading:11676473-Cell Division,
pubmed-meshheading:11676473-Cells, Cultured,
pubmed-meshheading:11676473-Cyclic AMP,
pubmed-meshheading:11676473-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:11676473-Male,
pubmed-meshheading:11676473-Membrane Proteins,
pubmed-meshheading:11676473-Muscle, Smooth, Vascular,
pubmed-meshheading:11676473-Peptides,
pubmed-meshheading:11676473-Phenotype,
pubmed-meshheading:11676473-RNA, Messenger,
pubmed-meshheading:11676473-Rats,
pubmed-meshheading:11676473-Rats, Wistar,
pubmed-meshheading:11676473-Receptor Activity-Modifying Protein 2,
pubmed-meshheading:11676473-Receptor Activity-Modifying Proteins,
pubmed-meshheading:11676473-Receptors, Adrenomedullin,
pubmed-meshheading:11676473-Receptors, Calcitonin,
pubmed-meshheading:11676473-Receptors, Peptide
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pubmed:year |
2001
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pubmed:articleTitle |
Phenotypic changes of adrenomedullin receptor components, RAMP2, and CRLR mRNA expression in cultured rat vascular smooth muscle cells.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, 814-0180, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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